Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	DL
Ref Reference (pH 7)	2.40	2.6	-135.91	7	9	2	124	583.685	↓ MOL2 SDF SMILES Flexibase
Hi High (pH 8-9.5)	2.40	-0.77	-19.64	5	9	0	122	581.669	↓ MOL2 SDF SMILES Flexibase
Hi High (pH 8-9.5)	2.40	0.88	-70.24	6	9	1	123	582.677	↓ MOL2 SDF SMILES Flexibase

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
OPRK-1-E	Kappa Opioid Receptor (cluster #1 Of 6), Eukaryotic	Eukaryotes	22	0.25	Binding ≤ 10μM
OPRM-1-E	Mu-type Opioid Receptor (cluster #1 Of 4), Eukaryotic	Eukaryotes	42	0.24	Binding ≤ 10μM
OPRD-1-E	Delta Opioid Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	170	0.22	Functional ≤ 10μM
OPRK-1-E	Kappa Opioid Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	2630	0.18	Functional ≤ 10μM
OPRM-1-E	Mu Opioid Receptor (cluster #1 Of 2), Eukaryotic	Eukaryotes	2630	0.18	Functional ≤ 10μM

ChEMBL Target Annotations
Uniprot	Swissprot	Description	Affinity (nM)	LE (kcal/mol/atom)	Type
OPRK_HUMAN	P41145	Kappa Opioid Receptor, Human	21.7	0.25	Binding ≤ 1μM
OPRM_HUMAN	P35372	Mu Opioid Receptor, Human	41.7	0.24	Binding ≤ 1μM
OPRK_HUMAN	P41145	Kappa Opioid Receptor, Human	21.7	0.25	Binding ≤ 10μM
OPRM_HUMAN	P35372	Mu Opioid Receptor, Human	41.7	0.24	Binding ≤ 10μM
OPRD_MOUSE	P32300	Delta Opioid Receptor, Mouse	170	0.22	Functional ≤ 10μM
OPRK_CAVPO	P41144	Kappa Opioid Receptor, Guinea Pig	250	0.21	Functional ≤ 10μM
OPRM_CAVPO	P97266	Mu Opioid Receptor, Guinea Pig	250	0.21	Functional ≤ 10μM

Description	Species
G alpha (i) signalling events	Mus musculus (OPRD_MOUSE) Homo sapiens (OPRM_HUMAN)
G-protein activation	Homo sapiens (OPRM_HUMAN)
Opioid Signalling	Homo sapiens (OPRM_HUMAN)
Peptide ligand-binding receptors	Mus musculus (OPRD_MOUSE) Homo sapiens (OPRM_HUMAN)