| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| July 19th, 2007 | 29 | Yes |
Popular Name: Lovastatin Lovastatin
Find On: PubMed — Wikipedia — Google
CAS Numbers: 75225-50-2 , 75330-75-5
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 4.35 | 1.49 | -14.26 | 1 | 5 | 0 | 72 | 404.547 | 7 | ↓ |
| Note Type | Comments | Provided By |
|---|---|---|
| Purity | USP24 | APIChem |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| HMDH-1-E | HMG-CoA Reductase (cluster #1 Of 2), Eukaryotic | Eukaryotes | 8 | 0.39 | Binding ≤ 10μM |
| HMDH-1-E | HMG-CoA Reductase (cluster #1 Of 2), Eukaryotic | Eukaryotes | 9 | 0.39 | Binding ≤ 10μM |
| Z81020-2-O | HepG2 (Hepatoblastoma Cells) (cluster #2 Of 8), Other | Other | 50 | 0.35 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| HMDH_HUMAN | P04035 | HMG-CoA Reductase, Human | 18 | 0.37 | Binding ≤ 1μM |
| HMDH_RAT | P51639 | HMG-CoA Reductase, Rat | 9.2 | 0.39 | Binding ≤ 1μM |
| HMDH_RAT | P51639 | HMG-CoA Reductase, Rat | 9.2 | 0.39 | Binding ≤ 10μM |
| HMDH_HUMAN | P04035 | HMG-CoA Reductase, Human | 18 | 0.37 | Binding ≤ 10μM |
| Z81020 | Z81020 | HepG2 (Hepatoblastoma Cells) | 50 | 0.35 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| Activation of gene expression by SREBF (SREBP) | |
| Cholesterol biosynthesis | |
| PPARA activates gene expression |
