UCSF

AMP-activated Protein Kinase, Beta-1 Subunit, Human (16 Compounds)

Swissprot:
AAKB1_HUMAN
Stitch:
AAKB1_HUMAN
UniProt:
Q9Y478
ChEMBL:
CHEMBL3847
Reactome:
REACT_200686
REACT_21285
REACT_21393
REACT_147867
PDB:
PRKAB1

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 16 2 0 1
Binding ≤ 1μM 6 1 0 1

Reactome Network (4)

Reactome ID Description Species
REACT_200686 Activation of PPARGC1A (PGC-1alpha) by phosphorylation Homo sapiens
REACT_21285 Regulation of AMPK activity via LKB1 Homo sapiens
REACT_21393 Regulation of Rheb GTPase activity by AMPK Homo sapiens
REACT_147867 Translocation of GLUT4 to the plasma membrane Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
AAKG1_HUMAN P54619 CHEMBL2393 AMP-activated Protein Kinase, Gamma-1 Subunit, Human 14
AAPK2_HUMAN P54646 CHEMBL2116 AMP-activated Protein Kinase, Alpha-2 Subunit, Human 14

Regulation of AMPK activity via LKB1

Uniprot Swissprot Chembl Description Number Shared
AAKG1_HUMAN P54619 CHEMBL2393 AMP-activated Protein Kinase, Gamma-1 Subunit, Human 14
AAPK2_HUMAN P54646 CHEMBL2116 AMP-activated Protein Kinase, Alpha-2 Subunit, Human 14

Regulation of Rheb GTPase activity by AMPK

Uniprot Swissprot Chembl Description Number Shared
AAKG1_HUMAN P54619 CHEMBL2393 AMP-activated Protein Kinase, Gamma-1 Subunit, Human 14
AAPK2_HUMAN P54646 CHEMBL2116 AMP-activated Protein Kinase, Alpha-2 Subunit, Human 14

Translocation of GLUT4 to the plasma membrane

Uniprot Swissprot Chembl Description Number Shared
AAKG1_HUMAN P54619 CHEMBL2393 AMP-activated Protein Kinase, Gamma-1 Subunit, Human 14
AAPK2_HUMAN P54646 CHEMBL2116 AMP-activated Protein Kinase, Alpha-2 Subunit, Human 14
AKT1_HUMAN P31749 CHEMBL4282 Serine/threonine-protein Kinase AKT, Human 1
AKT2_HUMAN P31751 CHEMBL2431 Serine/threonine-protein Kinase AKT2, Human 1

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
AAKG1_HUMAN P54619 CHEMBL2393 AMP-activated Protein Kinase, Gamma-1 Subunit, Human 14
AAPK2_HUMAN P54646 CHEMBL2116 AMP-activated Protein Kinase, Alpha-2 Subunit, Human 14
FLT3_HUMAN P36888 CHEMBL1974 Tyrosine-protein Kinase Receptor FLT3, Human 8
MKNK1_HUMAN Q9BUB5 CHEMBL4718 MAP Kinase-interacting Serine/threonine-protein Kinase MNK1, Human 8
SRC_HUMAN P12931 CHEMBL267 Tyrosine-protein Kinase SRC, Human 8
VGFR2_HUMAN P35968 CHEMBL279 Vascular Endothelial Growth Factor Receptor 2, Human 8
EPHA2_HUMAN P29317 CHEMBL2068 Ephrin Type-A Receptor 2, Human 7
KS6A1_HUMAN Q15418 CHEMBL2553 Ribosomal Protein S6 Kinase Alpha 1, Human 7
LCK_HUMAN P06239 CHEMBL258 Tyrosine-protein Kinase LCK, Human 7
VGFR1_HUMAN P17948 CHEMBL1868 Vascular Endothelial Growth Factor Receptor 1, Human 7
BMP4_HUMAN P12644 CHEMBL5350 Bone Morphogenetic Protein 4, Human 2
GSK3A_HUMAN P49840 CHEMBL2850 Glycogen Synthase Kinase-3 Alpha, Human 2
PIM1_HUMAN P11309 CHEMBL2147 Serine/threonine-protein Kinase PIM1, Human 2
AKT1_HUMAN P31749 CHEMBL4282 Serine/threonine-protein Kinase AKT, Human 1
AKT2_HUMAN P31751 CHEMBL2431 Serine/threonine-protein Kinase AKT2, Human 1
AKT3_HUMAN Q9Y243 CHEMBL4816 Serine/threonine-protein Kinase AKT3, Human 1
CDK2_HUMAN P24941 CHEMBL301 Cyclin-dependent Kinase 2, Human 1
CHK1_HUMAN O14757 CHEMBL4630 Serine/threonine-protein Kinase Chk1, Human 1
DAPK3_HUMAN O43293 CHEMBL2468 Death-associated Protein Kinase 3, Human 1
DYR1A_HUMAN Q13627 CHEMBL2292 Dual-specificity Tyrosine-phosphorylation Regulated Kinase 1A, Human 1
IRAK1_HUMAN P51617 CHEMBL3357 Interleukin-1 Receptor-associated Kinase 1, Human 1
KIT_HUMAN P10721 CHEMBL1936 Stem Cell Growth Factor Receptor, Human 1
KS6A4_HUMAN O75676 CHEMBL3125 Ribosomal Protein S6 Kinase Alpha 4, Human 1
MAPK2_HUMAN P49137 CHEMBL2208 MAP Kinase-activated Protein Kinase 2, Human 1
MARK2_HUMAN Q7KZI7 CHEMBL3831 MAP/microtubule Affinity-regulating Kinase 2, Human 1
MK13_HUMAN O15264 CHEMBL2939 MAP Kinase P38 Delta, Human 1
PDK1_HUMAN Q15118 CHEMBL4766 Pyruvate Dehydrogenase Kinase Isoform 1, Human 1
PIM2_HUMAN Q9P1W9 CHEMBL4523 Serine/threonine-protein Kinase PIM2, Human 1
PLK1_HUMAN P53350 CHEMBL3024 Serine/threonine-protein Kinase PLK1, Human 1
PLK3_HUMAN Q9H4B4 CHEMBL4897 Serine/threonine-protein Kinase PLK3, Human 1
SGK1_HUMAN O00141 CHEMBL2343 Serine/threonine-protein Kinase Sgk1, Human 1
SRPK1_HUMAN Q96SB4 CHEMBL4375 Serine/threonine-protein Kinase SRPK1, Human 1
TOPK_HUMAN Q96KB5 CHEMBL4896 PDZ-binding Kinase, Human 1
VGFR3_HUMAN P35916 CHEMBL1955 Vascular Endothelial Growth Factor Receptor 3, Human 1

Most Common Rings