UCSF

Neuronal Acetylcholine Receptor Protein Alpha-4 Subunit, Human (140 Compounds)

Swissprot:
ACHA4_HUMAN
Stitch:
ACHA4_HUMAN
UniProt:
P43681
ChEMBL:
CHEMBL1882
Reactome:
REACT_22352
REACT_22303
REACT_22223
PDB:
2GVT (DOCK)
CHRNA4

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 140 21 4 4
Binding ≤ 1μM 99 21 4 4
Functional ≤ 10μM 17 4 3 1
Uniprot Swissprot Chembl Description Number Shared
ACHA2_HUMAN Q15822 CHEMBL1794 Neuronal Acetylcholine Receptor Protein Alpha-2 Subunit, Human 17
ACHA3_HUMAN P32297 CHEMBL3068 Neuronal Acetylcholine Receptor Protein Alpha-3 Subunit, Human 59
ACHA5_HUMAN P30532 CHEMBL2454 Neuronal Acetylcholine Receptor Protein Alpha-5 Subunit, Human 5
ACHA6_HUMAN Q15825 CHEMBL2356 Neuronal Acetylcholine Receptor Protein Alpha-6 Subunit, Human 5
ACHA_HUMAN P02708 CHEMBL4808 Acetylcholine Receptor Protein Alpha Chain, Human 8
ACHB2_HUMAN P17787 CHEMBL1883 Neuronal Acetylcholine Receptor Protein Beta-2 Subunit, Human 36
ACHB3_HUMAN Q05901 CHEMBL2586 Neuronal Acetylcholine Receptor Protein Beta-3 Subunit, Human 25
ACHB4_HUMAN P30926 CHEMBL3002 Neuronal Acetylcholine Receptor Protein Beta-4 Subunit, Human 36

Highly calcium permeable postsynaptic nicotinic acetylcholine receptors

Uniprot Swissprot Chembl Description Number Shared
ACHA2_HUMAN Q15822 CHEMBL1794 Neuronal Acetylcholine Receptor Protein Alpha-2 Subunit, Human 17
ACHA3_HUMAN P32297 CHEMBL3068 Neuronal Acetylcholine Receptor Protein Alpha-3 Subunit, Human 59
ACHA5_HUMAN P30532 CHEMBL2454 Neuronal Acetylcholine Receptor Protein Alpha-5 Subunit, Human 5
ACHA6_HUMAN Q15825 CHEMBL2356 Neuronal Acetylcholine Receptor Protein Alpha-6 Subunit, Human 5
ACHA7_HUMAN P36544 CHEMBL2492 Neuronal Acetylcholine Receptor Protein Alpha-7 Subunit, Human 32
ACHA9_HUMAN Q9UGM1 CHEMBL2184 Neuronal Acetylcholine Receptor Protein Alpha-9 Subunit, Human 1
ACHA_HUMAN P02708 CHEMBL4808 Acetylcholine Receptor Protein Alpha Chain, Human 8
ACHB2_HUMAN P17787 CHEMBL1883 Neuronal Acetylcholine Receptor Protein Beta-2 Subunit, Human 36
ACHB3_HUMAN Q05901 CHEMBL2586 Neuronal Acetylcholine Receptor Protein Beta-3 Subunit, Human 25
ACHB4_HUMAN P30926 CHEMBL3002 Neuronal Acetylcholine Receptor Protein Beta-4 Subunit, Human 36

Highly sodium permeable acetylcholine nicotinic receptors

Uniprot Swissprot Chembl Description Number Shared
ACHA3_HUMAN P32297 CHEMBL3068 Neuronal Acetylcholine Receptor Protein Alpha-3 Subunit, Human 59
ACHB2_HUMAN P17787 CHEMBL1883 Neuronal Acetylcholine Receptor Protein Beta-2 Subunit, Human 36
ACHB4_HUMAN P30926 CHEMBL3002 Neuronal Acetylcholine Receptor Protein Beta-4 Subunit, Human 36
ACHD_HUMAN Q07001 CHEMBL3011 Acetylcholine Receptor Protein Delta Chain, Human 6
ACHE_HUMAN Q04844 CHEMBL2484 Acetylcholine Receptor Protein Epsilon Chain, Human 4
ACHG_HUMAN P07510 CHEMBL2613 Acetylcholine Receptor Protein Gamma Chain, Human 4
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
ACHA4_CHICK P09482 CHEMBL5569 Neuronal Acetylcholine Receptor Subunit Alpha-4, Chick 4 2 2 2
ACHA4_MOUSE O70174 CHEMBL4457 Neuronal Acetylcholine Receptor Protein Alpha-4 Subunit, Mouse 17 8 5 1
ACHA4_RAT P09483 CHEMBL307 Neuronal Acetylcholine Receptor Protein Alpha-4 Subunit, Rat 472 78 25 10
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
ACHA2_HUMAN Q15822 CHEMBL1794 Neuronal Acetylcholine Receptor Protein Alpha-2 Subunit, Human 24 6 4 4
ACHA3_HUMAN P32297 CHEMBL3068 Neuronal Acetylcholine Receptor Protein Alpha-3 Subunit, Human 84 15 7 7
ACHA5_HUMAN P30532 CHEMBL2454 Neuronal Acetylcholine Receptor Protein Alpha-5 Subunit, Human 5 3 1 0
ACHA6_HUMAN Q15825 CHEMBL2356 Neuronal Acetylcholine Receptor Protein Alpha-6 Subunit, Human 5 3 1 0
ACHA7_HUMAN P36544 CHEMBL2492 Neuronal Acetylcholine Receptor Protein Alpha-7 Subunit, Human 142 31 15 10
ACHA9_HUMAN Q9UGM1 CHEMBL2184 Neuronal Acetylcholine Receptor Protein Alpha-9 Subunit, Human 1 1 0 0
ACHA_HUMAN P02708 CHEMBL4808 Acetylcholine Receptor Protein Alpha Chain, Human 8 3 1 0

Clustered By Gene (0)

Clustered By Organism (4)

Code Description Substances Purchasable Natural In Man
ACHA4-1-E Neuronal Acetylcholine Receptor Protein Alpha-4 Subunit (cluster #1 Of 5), Eukaryotic 338 72 22 10
ACHA4-2-E Neuronal Acetylcholine Receptor Protein Alpha-4 Subunit (cluster #2 Of 5), Eukaryotic 1 1 1 0
ACHA4-3-E Neuronal Acetylcholine Receptor Protein Alpha-4 Subunit (cluster #3 Of 5), Eukaryotic 117 17 1 1
ACHA4-4-E Neuronal Acetylcholine Receptor Protein Alpha-4 Subunit (cluster #4 Of 5), Eukaryotic 85 0 0 0
ACHA4-5-E Neuronal Acetylcholine Receptor Protein Alpha-4 Subunit (cluster #5 Of 5), Eukaryotic 80 9 5 2
Uniprot Swissprot Chembl Description Number Shared
ACHA3_HUMAN P32297 CHEMBL3068 Neuronal Acetylcholine Receptor Protein Alpha-3 Subunit, Human 58
Z104290 Z104290 CHEMBL1907596 Neuronal Acetylcholine Receptor; Alpha4/beta2 55
ACHB2_HUMAN P17787 CHEMBL1883 Neuronal Acetylcholine Receptor Protein Beta-2 Subunit, Human 36
ACHB4_HUMAN P30926 CHEMBL3002 Neuronal Acetylcholine Receptor Protein Beta-4 Subunit, Human 36
Z104283 Z104283 CHEMBL1907589 Neuronal Acetylcholine Receptor; Alpha4/beta2 34
ACHA7_HUMAN P36544 CHEMBL2492 Neuronal Acetylcholine Receptor Protein Alpha-7 Subunit, Human 31
ACHB3_HUMAN Q05901 CHEMBL2586 Neuronal Acetylcholine Receptor Protein Beta-3 Subunit, Human 24
ACHB2_RAT P12390 CHEMBL3001 Neuronal Acetylcholine Receptor Protein Beta-2 Subunit, Rat 18
ACHA2_HUMAN Q15822 CHEMBL1794 Neuronal Acetylcholine Receptor Protein Alpha-2 Subunit, Human 17
ACHB4_RAT P12392 CHEMBL2658 Neuronal Acetylcholine Receptor Protein Beta-4 Subunit, Rat 16
ACHA4_RAT P09483 CHEMBL307 Neuronal Acetylcholine Receptor Protein Alpha-4 Subunit, Rat 11
ACHA3_RAT P04757 CHEMBL3818 Neuronal Acetylcholine Receptor Protein Alpha-3 Subunit, Rat 10
Z104287 Z104287 CHEMBL1907593 Neuronal Acetylcholine Receptor; Alpha3/beta4 10
ACHA7_RAT Q05941 CHEMBL4980 Neuronal Acetylcholine Receptor Protein Alpha-7 Subunit, Rat 9
ACHD_TORCA P02718 CHEMBL3916 Acetylcholine Receptor Protein Delta Chain, Torca 9
ACHA_HUMAN P02708 CHEMBL4808 Acetylcholine Receptor Protein Alpha Chain, Human 8
ACHA2_RAT P12389 CHEMBL2584 Neuronal Acetylcholine Receptor Protein Alpha-2 Subunit, Rat 6
ACHA9_RAT P43144 CHEMBL2585 Neuronal Acetylcholine Receptor Protein Alpha-9 Subunit, Rat 6
ACHD_HUMAN Q07001 CHEMBL3011 Acetylcholine Receptor Protein Delta Chain, Human 6
ACH10_HUMAN Q9GZZ6 CHEMBL2551 Neuronal Acetylcholine Receptor Protein Alpha-10 Subunit, Human 5
ACHA5_HUMAN P30532 CHEMBL2454 Neuronal Acetylcholine Receptor Protein Alpha-5 Subunit, Human 5
ACHA6_HUMAN Q15825 CHEMBL2356 Neuronal Acetylcholine Receptor Protein Alpha-6 Subunit, Human 5
ACHA_TORCA P02710 CHEMBL3097 Acetylcholine Receptor Protein Alpha Chain, Torca 5
Z104281 Z104281 CHEMBL1907587 Neuronal Acetylcholine Receptor; Alpha3/beta2 5
Z104286 Z104286 CHEMBL1907592 Neuronal Acetylcholine Receptor; Alpha2/beta2 5
Z104288 Z104288 CHEMBL1907594 Neuronal Acetylcholine Receptor; Alpha3/beta4 5
Z104289 Z104289 CHEMBL1907595 Neuronal Acetylcholine Receptor; Alpha4/beta4 5
ACH10_RAT Q9JLB5 CHEMBL3461 Neuronal Acetylcholine Receptor Protein Alpha-10 Subunit, Rat 4
ACHA5_RAT P20420 CHEMBL4960 Neuronal Acetylcholine Receptor Protein Alpha-5 Subunit, Rat 4
ACHA6_RAT P43143 CHEMBL4747 Neuronal Acetylcholine Receptor Protein Alpha-6 Subunit, Rat 4
ACHA_RAT P25108 CHEMBL3599 Acetylcholine Receptor Protein Alpha Chain, Rat 4
ACHB3_RAT P12391 CHEMBL4568 Neuronal Acetylcholine Receptor Protein Beta-3 Subunit, Rat 4
ACHB_HUMAN P11230 CHEMBL3355 Acetylcholine Receptor Protein Beta Chain, Human 4
ACHB_RAT P25109 CHEMBL2666 Acetylcholine Receptor Protein Beta Chain, Rat 4
ACHB_TORCA P02712 CHEMBL3803 Acetylcholine Receptor Protein Beta Chain, Torca 4
ACHE_HUMAN Q04844 CHEMBL2484 Acetylcholine Receptor Protein Epsilon Chain, Human 4
ACHG_HUMAN P07510 CHEMBL2613 Acetylcholine Receptor Protein Gamma Chain, Human 4
ACHG_TORCA P02714 CHEMBL4019 Acetylcholine Receptor Protein Gamma Chain, Torca 4
Z104282 Z104282 CHEMBL1907588 Acetylcholine Receptor; Alpha1/beta1/delta/gamma 4
Z104284 Z104284 CHEMBL1907590 Neuronal Acetylcholine Receptor; Alpha2/beta4 4
Z81074 Z81074 CHEMBL614687 K177cell Line 4
ACHA4_MOUSE O70174 CHEMBL4457 Neuronal Acetylcholine Receptor Protein Alpha-4 Subunit, Mouse 3
ACHP_LYMST P58154 CHEMBL6084 Acetylcholine-binding Protein, Lymst 3
Q8BGP7_MOUSE Q8BGP7 CHEMBL2235 Neuronal Acetylcholine Receptor Protein Beta-2 Subunit, Mouse 3
Z104285 Z104285 CHEMBL1907591 Neuronal Acetylcholine Receptor; Alpha4/beta4 3
Z50597 Z50597 CHEMBL376 Rattus Norvegicus 3
Z80175 Z80175 CHEMBL614585 IMR-32 (Neuroblastoma Cells) 2
Z80545 Z80545 CHEMBL615012 TE-671 2
5HT3A_HUMAN P46098 CHEMBL1899 Serotonin 3a (5-HT3a) Receptor, Human 1
ACHA4_CHICK P09482 CHEMBL5569 Neuronal Acetylcholine Receptor Subunit Alpha-4, Chick 1
ACHA7_MOUSE P49582 CHEMBL3365 Neuronal Acetylcholine Receptor Protein Alpha-7 Subunit, Mouse 1
ACHA9_HUMAN Q9UGM1 CHEMBL2184 Neuronal Acetylcholine Receptor Protein Alpha-9 Subunit, Human 1
KCNH2_HUMAN Q12809 CHEMBL240 HERG, Human 1
Z50594 Z50594 CHEMBL375 Mus Musculus 1