UCSF

Cytochrome P450 2C8, Human (29 Compounds)

Swissprot:
CP2C8_HUMAN
Stitch:
CP2C8_HUMAN
UniProt:
P10632
ChEMBL:
CHEMBL3721
Reactome:
REACT_13797
REACT_150134
REACT_150417
REACT_13543
PDB:
1PQ2 (DOCK)
2NNH (DOCK)
2NNI (DOCK)
2NNJ (DOCK)
2VN0 (DOCK)
CYP2C8

Compound Summary

Annotation Type Substances Purchasable Natural In Man
ADME/T ≤ 10μM 29 3 3 3

Reactome Network (4)

Reactome ID Description Species
REACT_13797 CYP2E1 reactions Homo sapiens
REACT_150134 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Homo sapiens
REACT_150417 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Homo sapiens
REACT_13543 Xenobiotics Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
CP2C9_HUMAN P11712 CHEMBL3397 Cytochrome P450 2C9, Human 16
CP2CJ_HUMAN P33261 CHEMBL3622 Cytochrome P450 2C19, Human 4
CP2D6_HUMAN P10635 CHEMBL289 Cytochrome P450 2D6, Human 2

Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)

Uniprot Swissprot Chembl Description Number Shared
CP1A1_HUMAN P04798 CHEMBL2231 Cytochrome P450 1A1, Human 1
CP1A2_HUMAN P05177 CHEMBL3356 Cytochrome P450 1A2, Human 3
CP2C9_HUMAN P11712 CHEMBL3397 Cytochrome P450 2C9, Human 16
CP2CJ_HUMAN P33261 CHEMBL3622 Cytochrome P450 2C19, Human 4

Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)

Uniprot Swissprot Chembl Description Number Shared
CP1A1_HUMAN P04798 CHEMBL2231 Cytochrome P450 1A1, Human 1
CP1A2_HUMAN P05177 CHEMBL3356 Cytochrome P450 1A2, Human 3
CP2C9_HUMAN P11712 CHEMBL3397 Cytochrome P450 2C9, Human 16
CP2CJ_HUMAN P33261 CHEMBL3622 Cytochrome P450 2C19, Human 4

Xenobiotics

Uniprot Swissprot Chembl Description Number Shared
CP1A1_HUMAN P04798 CHEMBL2231 Cytochrome P450 1A1, Human 1
CP2C9_HUMAN P11712 CHEMBL3397 Cytochrome P450 2C9, Human 16
CP2CI_HUMAN P33260 CHEMBL2408 Cytochrome P450 2C18, Human 4
CP2CJ_HUMAN P33261 CHEMBL3622 Cytochrome P450 2C19, Human 4
CP2D6_HUMAN P10635 CHEMBL289 Cytochrome P450 2D6, Human 2
CP3A4_HUMAN P08684 CHEMBL340 Cytochrome P450 3A4, Human 4

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
CP2C9_HUMAN P11712 CHEMBL3397 Cytochrome P450 2C9, Human 16
CP2CI_HUMAN P33260 CHEMBL2408 Cytochrome P450 2C18, Human 4
CP2CJ_HUMAN P33261 CHEMBL3622 Cytochrome P450 2C19, Human 4
CP3A4_HUMAN P08684 CHEMBL340 Cytochrome P450 3A4, Human 4
CP1A2_HUMAN P05177 CHEMBL3356 Cytochrome P450 1A2, Human 3
CP2D6_HUMAN P10635 CHEMBL289 Cytochrome P450 2D6, Human 2
CP1A1_HUMAN P04798 CHEMBL2231 Cytochrome P450 1A1, Human 1

Most Common Rings