UCSF

Cytochrome P450 2D6, Human (1,286 Compounds)

Swissprot:
CP2D6_HUMAN
Stitch:
CP2D6_HUMAN
UniProt:
P10635
ChEMBL:
CHEMBL289
Reactome:
REACT_13797
REACT_13814
REACT_13425
REACT_13543
PDB:
2F9Q (DOCK)
CYP2D6

Compound Summary

Annotation Type Substances Purchasable Natural In Man
ADME/T ≤ 10μM 1,286 91 50 46

Reactome Network (4)

Reactome ID Description Species
REACT_13797 CYP2E1 reactions Homo sapiens
REACT_13814 Fatty acids Homo sapiens
REACT_13425 Miscellaneous substrates Homo sapiens
REACT_13543 Xenobiotics Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
CP2A6_HUMAN P11509 CHEMBL5282 Cytochrome P450 2A6, Human 2
CP2B6_HUMAN P20813 CHEMBL4729 Cytochrome P450 2B6, Human 5
CP2C8_HUMAN P10632 CHEMBL3721 Cytochrome P450 2C8, Human 2
CP2C9_HUMAN P11712 CHEMBL3397 Cytochrome P450 2C9, Human 132
CP2CJ_HUMAN P33261 CHEMBL3622 Cytochrome P450 2C19, Human 81
CP2E1_HUMAN P05181 CHEMBL5281 Cytochrome P450 2E1, Human 2

Fatty acids

Uniprot Swissprot Chembl Description Number Shared
CP2B6_HUMAN P20813 CHEMBL4729 Cytochrome P450 2B6, Human 5
CP4AB_HUMAN Q02928 CHEMBL3978 Cytochrome P450 4A11, Human 18
CP4F2_HUMAN P78329 CHEMBL3379 Cytochrome P450 4F2, Human 18

Miscellaneous substrates

Uniprot Swissprot Chembl Description Number Shared
CP343_HUMAN Q9HB55 CHEMBL5792 Cytochrome P450 3A43, Human 1
CP4AB_HUMAN Q02928 CHEMBL3978 Cytochrome P450 4A11, Human 18
CP4F2_HUMAN P78329 CHEMBL3379 Cytochrome P450 4F2, Human 18

Xenobiotics

Uniprot Swissprot Chembl Description Number Shared
CP2A6_HUMAN P11509 CHEMBL5282 Cytochrome P450 2A6, Human 2
CP2B6_HUMAN P20813 CHEMBL4729 Cytochrome P450 2B6, Human 5
CP2C8_HUMAN P10632 CHEMBL3721 Cytochrome P450 2C8, Human 2
CP2C9_HUMAN P11712 CHEMBL3397 Cytochrome P450 2C9, Human 132
CP2CJ_HUMAN P33261 CHEMBL3622 Cytochrome P450 2C19, Human 81
CP2E1_HUMAN P05181 CHEMBL5281 Cytochrome P450 2E1, Human 2
CP343_HUMAN Q9HB55 CHEMBL5792 Cytochrome P450 3A43, Human 1
CP3A4_HUMAN P08684 CHEMBL340 Cytochrome P450 3A4, Human 252

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
CP3A4_HUMAN P08684 CHEMBL340 Cytochrome P450 3A4, Human 252
CP2C9_HUMAN P11712 CHEMBL3397 Cytochrome P450 2C9, Human 132
CP2CJ_HUMAN P33261 CHEMBL3622 Cytochrome P450 2C19, Human 81
CP1A2_HUMAN P05177 CHEMBL3356 Cytochrome P450 1A2, Human 66
CP2DQ_RAT P10634 CHEMBL2483 Cytochrome P450 2D2, Rat 9
CP2B6_HUMAN P20813 CHEMBL4729 Cytochrome P450 2B6, Human 5
Z102164 Z102164 CHEMBL613373 Liver Microsomes 3
ADO_HUMAN Q06278 CHEMBL3257 Aldehyde Oxidase, Human 2
CP2A6_HUMAN P11509 CHEMBL5282 Cytochrome P450 2A6, Human 2
CP2C8_HUMAN P10632 CHEMBL3721 Cytochrome P450 2C8, Human 2
CP2E1_HUMAN P05181 CHEMBL5281 Cytochrome P450 2E1, Human 2
ADO_RABIT P80456 CHEMBL1641356 Aldehyde Oxidase, Rabit 1
ADO_RAT Q9Z0U5 CHEMBL1641355 Aldehyde Oxidase, Rat 1
CP2DI_RAT Q64680 CHEMBL4982 Cytochrome P450 2D18, Rat 1
CP343_HUMAN Q9HB55 CHEMBL5792 Cytochrome P450 3A43, Human 1
Z50460 Z50460 CHEMBL612879 Leishmania Major 1
Z80954 Z80954 CHEMBL614071 HFF (Foreskin Fibroblasts) 1

Most Common Rings