UCSF
ZINC Item Suppliers, Protomers, & Similar Substances

Analogs

39260312
39260312

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Popular Name: 3-(2-benzylphenoxy)-N-isopropyl-propan-1-amine 3-(2-benzylphenoxy)-N-isopropyl-…

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Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
FDFT-4-E Squalene Synthetase (cluster #4 Of 4), Eukaryotic Eukaryotes 12 0.53 Binding ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 4.64 10.75 -40.57 2 2 1 26 284.423 8 ↓

Analogs

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Popular Name: 3-(2-allylphenoxy)-N-isopropyl-propan-1-amine 3-(2-allylphenoxy)-N-isopropyl-p…

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Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
FDFT-4-E Squalene Synthetase (cluster #4 Of 4), Eukaryotic Eukaryotes 56 0.60 Binding ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.50 8.25 -38.48 2 2 1 26 234.363 8 ↓

Analogs

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Popular Name: Alpha-hydroxyfarnesylphosphonic acid Alpha-hydroxyfarnesylphosphonic …

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Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
FDFT-3-E Squalene Synthetase (cluster #3 Of 4), Eukaryotic Eukaryotes 2300 0.39 Binding ≤ 10μM
FNTA-2-E Protein Farnesyltransferase/geranylgeranyltransferase Type I Alpha Subunit (cluster #2 Of 3), Eukaryotic Eukaryotes 5 0.58 Binding ≤ 10μM
FNTB-2-E Protein Farnesyltransferase Beta Subunit (cluster #2 Of 3), Eukaryotic Eukaryotes 5 0.58 Binding ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.76 4.93 -45.96 2 4 -1 81 301.343 8 ↓

Analogs

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Popular Name: ¦Á-Hydroxyfarnesyl-phosphonicacid ¦Á-Hydroxyfarnesyl-phosphonicacid

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Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
FDFT-3-E Squalene Synthetase (cluster #3 Of 4), Eukaryotic Eukaryotes 2300 0.39 Binding ≤ 10μM
FNTA-2-E Protein Farnesyltransferase/geranylgeranyltransferase Type I Alpha Subunit (cluster #2 Of 3), Eukaryotic Eukaryotes 5 0.58 Binding ≤ 10μM
FNTB-2-E Protein Farnesyltransferase Beta Subunit (cluster #2 Of 3), Eukaryotic Eukaryotes 5 0.58 Binding ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.76 4.94 -47.26 2 4 -1 81 301.343 8 ↓

Analogs

3630929
3630929
32110192
32110192
32110193
32110193
32119111
32119111
32119113
32119113

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Popular Name: 1-(4-Biphenylyloxy)-3-(isopropylamino)-2-propanol hydrochloride; 2-Propanol, 1-(4-biphenylyloxy)-3-(isopropylamino)-, hydrochloride; LS-121740 1-(4-Biphenylyloxy)-3-(isopropyl…

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Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
FDFT-4-E Squalene Synthetase (cluster #4 Of 4), Eukaryotic Eukaryotes 3000 0.37 Binding ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.60 -1.89 -42.37 3 3 1 46 286.395 7 ↓

Analogs

32110192
32110192
32110193
32110193
32119111
32119111
32119113
32119113
36631477
36631477

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Popular Name: 1-(4-Biphenylyloxy)-3-(isopropylamino)-2-propanol hydrochloride; 2-Propanol, 1-(4-biphenylyloxy)-3-(isopropylamino)-, hydrochloride; LS-121740 1-(4-Biphenylyloxy)-3-(isopropyl…

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Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
FDFT-4-E Squalene Synthetase (cluster #4 Of 4), Eukaryotic Eukaryotes 3000 0.37 Binding ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.60 -1.94 -42.49 3 3 1 46 286.395 7 ↓

Analogs

86599
86599

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Popular Name: Alprenolol Alprenolol

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Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
ADRB1-2-E Beta-1 Adrenergic Receptor (cluster #2 Of 2), Eukaryotic Eukaryotes 2 0.68 Binding ≤ 10μM
ADRB2-1-E Beta-2 Adrenergic Receptor (cluster #1 Of 2), Eukaryotic Eukaryotes 3 0.66 Binding ≤ 10μM
ADRB3-2-E Beta-3 Adrenergic Receptor (cluster #2 Of 2), Eukaryotic Eukaryotes 2 0.68 Binding ≤ 10μM
FDFT-4-E Squalene Synthetase (cluster #4 Of 4), Eukaryotic Eukaryotes 4200 0.42 Binding ≤ 10μM
Z50425-11-O Plasmodium Falciparum (cluster #11 Of 22), Other Other 1995 0.44 Functional ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.58 5.16 -40.25 3 3 1 46 250.362 8 ↓
Hi High (pH 8-9.5) 2.58 3.88 -5.22 2 3 0 41 249.354 8 ↓

Analogs

3647816
3647816
3647817
3647817
23
23

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Popular Name: Alprenolol Alprenolol

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Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
ADRB1-2-E Beta-1 Adrenergic Receptor (cluster #2 Of 2), Eukaryotic Eukaryotes 2 0.68 Binding ≤ 10μM
ADRB2-1-E Beta-2 Adrenergic Receptor (cluster #1 Of 2), Eukaryotic Eukaryotes 3 0.66 Binding ≤ 10μM
ADRB3-2-E Beta-3 Adrenergic Receptor (cluster #2 Of 2), Eukaryotic Eukaryotes 2 0.68 Binding ≤ 10μM
FDFT-4-E Squalene Synthetase (cluster #4 Of 4), Eukaryotic Eukaryotes 4200 0.42 Binding ≤ 10μM
Z50425-11-O Plasmodium Falciparum (cluster #11 Of 22), Other Other 1995 0.44 Functional ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 2.58 5.19 -40.14 3 3 1 46 250.362 8 ↓
Hi High (pH 8-9.5) 2.58 4.01 -5.14 2 3 0 41 249.354 8 ↓

Analogs

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Popular Name: N-(1-azabicyclo[2.2.2]oct-3-yl)-N-([1,1'-biphenyl]-4-ylmethyl)amine N-(1-azabicyclo[2.2.2]oct-3-yl)-…

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Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
FDFT-3-E Squalene Synthetase (cluster #3 Of 4), Eukaryotic Eukaryotes 140 0.44 Binding ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.94 10.16 -38.13 2 2 1 16 293.434 4 ↓

Analogs

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Popular Name: N-(1-azabicyclo[2.2.2]oct-3-yl)-N-([1,1'-biphenyl]-4-ylmethyl)amine N-(1-azabicyclo[2.2.2]oct-3-yl)-…

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Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
FDFT-3-E Squalene Synthetase (cluster #3 Of 4), Eukaryotic Eukaryotes 140 0.44 Binding ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.94 10.24 -35.54 2 2 1 16 293.434 4 ↓

Analogs

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Popular Name: DNC009027 DNC009027

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Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
FDFT-1-E Squalene Synthetase (cluster #1 Of 4), Eukaryotic Eukaryotes 169 0.38 Binding ≤ 10μM
FDFT-1-E Squalene Synthetase (cluster #1 Of 4), Eukaryotic Eukaryotes 1900 0.32 Binding ≤ 10μM
CRTM-1-B Dehydrosqualene Synthase (cluster #1 Of 1), Bacterial Bacteria 1400 0.33 Binding ≤ 10μM
CRTM-1-B Dehydrosqualene Synthase (cluster #1 Of 1), Bacterial Bacteria 7900 0.29 Binding ≤ 10μM
Z50185-2-O Staphylococcus Aureus (cluster #2 Of 4), Other Other 50 0.41 Functional ≤ 10μM
Z50185-2-O Staphylococcus Aureus (cluster #2 Of 4), Other Other 110 0.39 Functional ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.44 4.21 -123.14 1 7 -2 127 384.346 8 ↓

Analogs

12494630
12494630
12495043
12495043
12495048
12495048
16343477
16343477
24973143
24973143

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Popular Name: farnesyl pyrophosphate farnesyl pyrophosphate

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Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
FDFT-3-E Squalene Synthetase (cluster #3 Of 4), Eukaryotic Eukaryotes 2600 0.33 Binding ≤ 10μM
FNTA-2-F Protein Farnesyltransferase/geranylgeranyltransferase Type I Alpha Subunit (cluster #2 Of 2), Fungal Fungi 75 0.42 Binding ≤ 10μM
FNTB-2-F Protein Farnesyltransferase Beta Subunit (cluster #2 Of 2), Fungal Fungi 75 0.42 Binding ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.37 9.67 -242.08 0 7 -3 122 379.306 11 ↓
Mid Mid (pH 6-8) 3.37 8.53 -122.03 1 7 -2 119 380.314 11 ↓

Analogs

14242978
14242978
14242979
14242979
14242980
14242980

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Popular Name: Agaricin Agaricin

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Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
FDFT-1-E Squalene Synthetase (cluster #1 Of 4), Eukaryotic Eukaryotes 9000 0.24 Binding ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 6.12 15.31 -225.67 1 7 -3 141 413.531 20 ↓
Lo Low (pH 4.5-6) 6.12 13.33 -127.79 2 7 -2 138 414.539 20 ↓
Lo Low (pH 4.5-6) 6.12 13 -128.44 2 7 -2 138 414.539 20 ↓

Analogs

14242979
14242979
14242980
14242980
6920374
6920374

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Popular Name: Agaricin Agaricin

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Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
FDFT-1-E Squalene Synthetase (cluster #1 Of 4), Eukaryotic Eukaryotes 9000 0.24 Binding ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 6.12 15.66 -208.52 1 7 -3 141 413.531 20 ↓
Lo Low (pH 4.5-6) 6.12 13.68 -109.24 2 7 -2 138 414.539 20 ↓
Lo Low (pH 4.5-6) 6.12 13.16 -124.37 2 7 -2 138 414.539 20 ↓

Analogs

14242980
14242980
14242978
14242978
6920374
6920374

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Popular Name: Agaricin Agaricin

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Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
FDFT-1-E Squalene Synthetase (cluster #1 Of 4), Eukaryotic Eukaryotes 9000 0.24 Binding ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 6.12 15.55 -208.59 1 7 -3 141 413.531 20 ↓
Lo Low (pH 4.5-6) 6.12 11.13 -53.92 3 7 -1 135 415.547 20 ↓
Lo Low (pH 4.5-6) 6.12 13.57 -108.9 2 7 -2 138 414.539 20 ↓

Analogs

14242978
14242978
14242979
14242979

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Popular Name: Agaricin Agaricin

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Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
FDFT-1-E Squalene Synthetase (cluster #1 Of 4), Eukaryotic Eukaryotes 9000 0.24 Binding ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 6.12 14.8 -228.05 1 7 -3 141 413.531 20 ↓
Lo Low (pH 4.5-6) 6.12 11.29 -57.33 3 7 -1 135 415.547 20 ↓
Lo Low (pH 4.5-6) 6.12 13.27 -125.06 2 7 -2 138 414.539 20 ↓

Analogs

7538283
7538283
34825504
34825504
34832387
34832387
34832389
34832389
34832391
34832391

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Popular Name: Benzyl-(4-benzyloxy-benzyl)-amine Benzyl-(4-benzyloxy-benzyl)-amine

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Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
FDFT-4-E Squalene Synthetase (cluster #4 Of 4), Eukaryotic Eukaryotes 55 0.44 Binding ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 4.55 0.38 -46.28 2 2 1 25 304.413 7 ↓

Analogs

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Popular Name: Ibandronate sodium Ibandronate sodium

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Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
FDFT-2-E Squalene Synthetase (cluster #2 Of 4), Eukaryotic Eukaryotes 640 0.46 Binding ≤ 10μM
FPPS-1-E Farnesyl Diphosphate Synthase (cluster #1 Of 1), Eukaryotic Eukaryotes 480 0.47 Binding ≤ 10μM
Z50725-4-O Trypanosoma Brucei Rhodesiense (cluster #4 Of 7), Other Other 960 0.44 Functional ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -0.56 -0.37 -173.95 3 8 -2 148 317.215 9 ↓
Hi High (pH 8-9.5) -0.56 0.81 -304.39 2 8 -3 151 316.207 9 ↓
Mid Mid (pH 6-8) -0.56 -1.47 -87.19 4 8 -1 145 318.223 9 ↓

Parameters Provided:

annotation.name = FDFT_RAT
anotation.type = B10
page.format = summary
page.num = 1
filter.purchasability = purchasable

Structural Results Found: (before additional filtering)

SQL Query Was

SELECT DISTINCT(ci.sub_id_fk) AS sub_id FROM catalog_item AS ci INNER JOIN catalog AS c ON ci.cat_id_fk=c.cat_id INNER JOIN note AS n ON ci.sub_id_fk=n.sub_id_fk INNER JOIN annotation AS a ON n.anno_id_fk=a.anno_id  WHERE c.free = 1 AND a.short_desc LIKE 'FDFT\\_RAT' AND c.purchasable IN (1,2,4,5)    LIMIT 50

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