UCSF

Dual Specificity Phosphatase Cdc25A, Human (164 Compounds)

Swissprot:
MPIP1_HUMAN
Stitch:
MPIP1_HUMAN
UniProt:
P30304
ChEMBL:
CHEMBL3775
Reactome:
REACT_6769
REACT_1857
REACT_9029
REACT_2101
REACT_1574
REACT_471
REACT_1321
REACT_111214
REACT_683
REACT_2160
REACT_1006
REACT_1614
PDB:
1C25 (DOCK)
CDC25A

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 164 27 4 1
Binding ≤ 1μM 33 5 2 1

Reactome Network (12)

Reactome ID Description Species
REACT_6769 Activation of ATR in response to replication stress Homo sapiens
REACT_1857 Cyclin A/B1 associated events during G2/M transition Homo sapiens
REACT_9029 Cyclin A:Cdk2-associated events at S phase entry Homo sapiens
REACT_2101 Cyclin B2 mediated events Homo sapiens
REACT_1574 Cyclin E associated events during G1/S transition Homo sapiens
REACT_471 E2F mediated regulation of DNA replication Homo sapiens
REACT_1321 E2F-enabled inhibition of pre-replication complex formation Homo sapiens
REACT_111214 G0 and Early G1 Homo sapiens
REACT_683 G1/S-Specific Transcription Homo sapiens
REACT_2160 p53-Independent DNA Damage Response Homo sapiens
REACT_1006 Polo-like kinase mediated events Homo sapiens
REACT_1614 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
CDC45_HUMAN O75419 CHEMBL3040 CDC45-related Protein, Human 4
MPIP3_HUMAN P30307 CHEMBL2378 Dual Specificity Phosphatase Cdc25C, Human 15

Cyclin A/B1 associated events during G2/M transition

Uniprot Swissprot Chembl Description Number Shared
MPIP2_HUMAN P30305 CHEMBL4804 Dual Specificity Phosphatase Cdc25B, Human 89
MPIP3_HUMAN P30307 CHEMBL2378 Dual Specificity Phosphatase Cdc25C, Human 15

Cyclin A:Cdk2-associated events at S phase entry

Uniprot Swissprot Chembl Description Number Shared
MPIP2_HUMAN P30305 CHEMBL4804 Dual Specificity Phosphatase Cdc25B, Human 89

Cyclin B2 mediated events

Uniprot Swissprot Chembl Description Number Shared
MPIP2_HUMAN P30305 CHEMBL4804 Dual Specificity Phosphatase Cdc25B, Human 89
MPIP3_HUMAN P30307 CHEMBL2378 Dual Specificity Phosphatase Cdc25C, Human 15

E2F mediated regulation of DNA replication

Uniprot Swissprot Chembl Description Number Shared
CDC45_HUMAN O75419 CHEMBL3040 CDC45-related Protein, Human 4

G1/S-Specific Transcription

Uniprot Swissprot Chembl Description Number Shared
CDC45_HUMAN O75419 CHEMBL3040 CDC45-related Protein, Human 4

Polo-like kinase mediated events

Uniprot Swissprot Chembl Description Number Shared
MPIP3_HUMAN P30307 CHEMBL2378 Dual Specificity Phosphatase Cdc25C, Human 15
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
MPIP2_HUMAN P30305 CHEMBL4804 Dual Specificity Phosphatase Cdc25B, Human 240 48 6 2
MPIP3_HUMAN P30307 CHEMBL2378 Dual Specificity Phosphatase Cdc25C, Human 24 2 0 0

Clustered By Gene (0)

Clustered By Organism (1)

Code Description Substances Purchasable Natural In Man
MPIP1-1-E Dual Specificity Phosphatase Cdc25A (cluster #1 Of 2), Eukaryotic 98 1 4 1
MPIP1-2-E Dual Specificity Phosphatase Cdc25A (cluster #2 Of 2), Eukaryotic 73 26 0 0
Uniprot Swissprot Chembl Description Number Shared
MPIP2_HUMAN P30305 CHEMBL4804 Dual Specificity Phosphatase Cdc25B, Human 89
DUS3_HUMAN P51452 CHEMBL2635 Dual Specificity Protein Phosphatase 3, Human 15
MPIP3_HUMAN P30307 CHEMBL2378 Dual Specificity Phosphatase Cdc25C, Human 15
PTN1_HUMAN P18031 CHEMBL335 Protein-tyrosine Phosphatase 1B, Human 13
PTPRC_HUMAN P08575 CHEMBL3243 Leukocyte Common Antigen, Human 10
CDC45_HUMAN O75419 CHEMBL3040 CDC45-related Protein, Human 4
DUS1_HUMAN P28562 CHEMBL6026 Dual Specificity Protein Phosphatase 1, Human 4
PTN7_HUMAN P35236 CHEMBL2219 Protein-tyrosine Phosphatase LC-PTP, Human 4
PP1G_HUMAN P36873 CHEMBL4438 Serine/threonine Protein Phosphatase PP1-gamma Catalytic Subunit, Human 2
YOPH_YEREN P15273 CHEMBL4404 Tyrosine-protein Phosphatase YopH, Yeren 2
PTPRF_HUMAN P10586 CHEMBL3521 Receptor-type Tyrosine-protein Phosphatase F (LAR), Human 1

Most Common Rings