UCSF

Phosphatidylinositol 3-kinase Catalytic Subunit Type 3, Human (4 Compounds)

Swissprot:
PK3C3_HUMAN
Stitch:
PK3C3_HUMAN
UniProt:
Q8NEB9
ChEMBL:
CHEMBL1075165
Reactome:
REACT_976
REACT_120756
REACT_120836
REACT_120918
REACT_9047
PDB:
3IHY (DOCK)
3LS8 (DOCK)
PIK3C3

Compound Summary

Annotation Type Substances Purchasable Natural In Man
Binding ≤ 10μM 4 2 0 0
Binding ≤ 1μM 4 2 0 0

Reactome Network (5)

Reactome ID Description Species
REACT_976 PI3K Cascade Homo sapiens
REACT_120756 Synthesis of PIPs at the early endosome membrane Homo sapiens
REACT_120836 Synthesis of PIPs at the Golgi membrane Homo sapiens
REACT_120918 Synthesis of PIPs at the late endosome membrane Homo sapiens
REACT_9047 Toll Like Receptor 9 (TLR9) Cascade Homo sapiens
Uniprot Swissprot Chembl Description Number Shared
P85A_HUMAN P27986 CHEMBL2506 PI3-kinase P85-alpha Subunit, Human 3
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 4
PK3CB_HUMAN P42338 CHEMBL3145 PI3-kinase P110-beta Subunit, Human 1

Synthesis of PIPs at the early endosome membrane

Uniprot Swissprot Chembl Description Number Shared
P3C2A_HUMAN O00443 CHEMBL1075102 Phosphatidylinositol-4-phosphate 3-kinase C2 Domain-containing Subunit Alpha, Human 3

Synthesis of PIPs at the Golgi membrane

Uniprot Swissprot Chembl Description Number Shared
P3C2A_HUMAN O00443 CHEMBL1075102 Phosphatidylinositol-4-phosphate 3-kinase C2 Domain-containing Subunit Alpha, Human 3
PI4KB_HUMAN Q9UBF8 CHEMBL3268 PI4-kinase Beta Subunit, Human 3

Synthesis of PIPs at the late endosome membrane

Uniprot Swissprot Chembl Description Number Shared
P3C2A_HUMAN O00443 CHEMBL1075102 Phosphatidylinositol-4-phosphate 3-kinase C2 Domain-containing Subunit Alpha, Human 3
UniProt Swissprot ChEMBL Description Substances Purchasable Natural In Man
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 1,234 42 4 9
PK3CB_HUMAN P42338 CHEMBL3145 PI3-kinase P110-beta Subunit, Human 290 24 3 8
PK3CD_HUMAN O00329 CHEMBL3130 PI3-kinase P110-delta Subunit, Human 374 25 4 10
PK3CG_HUMAN P48736 CHEMBL3267 PI3-kinase P110-gamma Subunit, Human 596 31 3 9

Clustered By Gene (0)

Uniprot Swissprot Chembl Description Number Shared
PK3CA_HUMAN P42336 CHEMBL4005 PI3-kinase P110-alpha Subunit, Human 4
PK3CD_HUMAN O00329 CHEMBL3130 PI3-kinase P110-delta Subunit, Human 4
PK3CG_HUMAN P48736 CHEMBL3267 PI3-kinase P110-gamma Subunit, Human 4
MTOR_HUMAN P42345 CHEMBL2842 FK506 Binding Protein 12, Human 3
MTOR_MOUSE Q9JLN9 CHEMBL1255165 Serine/threonine-protein Kinase MTOR, Mouse 3
P3C2A_HUMAN O00443 CHEMBL1075102 Phosphatidylinositol-4-phosphate 3-kinase C2 Domain-containing Subunit Alpha, Human 3
P3C2B_HUMAN O00750 CHEMBL5554 Phosphatidylinositol-4-phosphate 3-kinase C2 Domain-containing Beta Polypeptide, Human 3
P85A_HUMAN P27986 CHEMBL2506 PI3-kinase P85-alpha Subunit, Human 3
PI4KB_HUMAN Q9UBF8 CHEMBL3268 PI4-kinase Beta Subunit, Human 3
PRKDC_HUMAN P78527 CHEMBL3142 DNA-dependent Protein Kinase, Human 3
AKT1_HUMAN P31749 CHEMBL4282 Serine/threonine-protein Kinase AKT, Human 1
MRCKA_HUMAN Q5VT25 CHEMBL4516 Serine/threonine-protein Kinase MRCK-A, Human 1
PK3CB_HUMAN P42338 CHEMBL3145 PI3-kinase P110-beta Subunit, Human 1

Most Common Rings