UCSF
ZINC Item Suppliers, Protomers, & Similar Substances

Analogs

16343477
16343477
24973143
24973143
12494625
12494625

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Popular Name: geranylgeranyl diphosphate geranylgeranyl diphosphate

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL

Analogs

12495043
12495043
16343477
16343477
24973143
24973143
12494625
12494625

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Popular Name: farnesyl pyrophosphate farnesyl pyrophosphate

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL

Analogs

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Popular Name: Geranyl-PP Geranyl-PP

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Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
Z50725-6-O Trypanosoma Brucei Rhodesiense (cluster #6 Of 7), Other Other 3710 0.40 Functional ≤ 10μM
ChEMBL Target Annotations
Uniprot Swissprot Description Affinity (nM) LE (kcal/mol/atom) Type
Z50725 Z50725 Trypanosoma Brucei Rhodesiense 3710 0.40 Functional ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL

Analogs

8215654
8215654

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Popular Name: isopentenyl pyrophosphate isopentenyl pyrophosphate

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL

Analogs

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Popular Name: Dimethylallylpyrophosphate Dimethylallylpyrophosphate

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL

Analogs

12495048
12495048
16343477
16343477
24973143
24973143
12494625
12494625

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Popular Name: geranylgeranyl diphosphate geranylgeranyl diphosphate

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 5.22 13.2 -242.32 0 7 -3 122 447.425 14 ↓
Mid Mid (pH 6-8) 5.22 12.05 -122.23 1 7 -2 119 448.433 14 ↓

Analogs

12494630
12494630
12495043
12495043
12495048
12495048
16343477
16343477
24973143
24973143

Draw Identity 99% 90% 80% 70%

Popular Name: farnesyl pyrophosphate farnesyl pyrophosphate

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Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
FDFT-3-E Squalene Synthetase (cluster #3 Of 4), Eukaryotic Eukaryotes 2600 0.33 Binding ≤ 10μM
FNTA-2-F Protein Farnesyltransferase/geranylgeranyltransferase Type I Alpha Subunit (cluster #2 Of 2), Fungal Fungi 75 0.42 Binding ≤ 10μM
FNTB-2-F Protein Farnesyltransferase Beta Subunit (cluster #2 Of 2), Fungal Fungi 75 0.42 Binding ≤ 10μM
ChEMBL Target Annotations
Uniprot Swissprot Description Affinity (nM) LE (kcal/mol/atom) Type
FNTB_YEAST P22007 Protein Farnesyltransferase Beta Subunit, Yeast 75 0.42 Binding ≤ 1μM
FNTA_YEAST P29703 Protein Farnesyltransferase/geranylgeranyltransferase Type I Alpha Subunit, Yeast 75 0.42 Binding ≤ 1μM
FNTB_YEAST P22007 Protein Farnesyltransferase Beta Subunit, Yeast 75 0.42 Binding ≤ 10μM
FNTA_YEAST P29703 Protein Farnesyltransferase/geranylgeranyltransferase Type I Alpha Subunit, Yeast 75 0.42 Binding ≤ 10μM
FDFT_RAT Q02769 Squalene Synthetase, Rat 2600 0.33 Binding ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 3.37 9.67 -242.08 0 7 -3 122 379.306 11 ↓
Mid Mid (pH 6-8) 3.37 8.53 -122.03 1 7 -2 119 380.314 11 ↓

Analogs

13507556
13507556
34661063
34661063

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Popular Name: Geranyl-PP Geranyl-PP

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Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
Z50725-6-O Trypanosoma Brucei Rhodesiense (cluster #6 Of 7), Other Other 3710 0.40 Functional ≤ 10μM
ChEMBL Target Annotations
Uniprot Swissprot Description Affinity (nM) LE (kcal/mol/atom) Type
Z50725 Z50725 Trypanosoma Brucei Rhodesiense 3710 0.40 Functional ≤ 10μM

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 1.53 6.17 -241.74 0 7 -3 122 311.187 8 ↓
Mid Mid (pH 6-8) 1.53 5.02 -121.89 1 7 -2 119 312.195 8 ↓

Analogs

12495077
12495077

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Popular Name: ISOPENTENYL PYROPHOSPHATE ISOPENTENYL PYROPHOSPHATE

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -0.53 2.65 -236.75 0 7 -3 122 243.068 6 ↓
Mid Mid (pH 6-8) -0.53 1.49 -118.99 1 7 -2 119 244.076 6 ↓

Analogs

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Popular Name: Dimethylallylpyrophosphate Dimethylallylpyrophosphate

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Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) -0.32 2.67 -239.84 0 7 -3 122 243.068 5 ↓
Mid Mid (pH 6-8) -0.32 1.51 -121.23 1 7 -2 119 244.076 5 ↓

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