In ZINC since | Heavy atoms | Benign functionality |
---|---|---|
November 12th, 2007 | 29 | Yes |
Popular Name: 1-[4-(chloroBLAHylidene)-1-piperidyl]-3,3-dimethyl-butan-1-one 1-[4-(chloroBLAHylidene)-1-piper…
Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
---|---|---|---|---|---|---|---|---|---|---|
Ref Reference (pH 7) | 5.42 | 1.65 | -8.46 | 0 | 3 | 0 | 33 | 408.973 | 2 | ↓ |
Lo Low (pH 4.5-6) | 5.42 | 1.72 | -42.85 | 1 | 3 | 1 | 34 | 409.981 | 2 | ↓ |
Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
FNTA-1-E | Protein Farnesyltransferase/geranylgeranyltransferase Type I Alpha Subunit (cluster #1 Of 3), Eukaryotic | Eukaryotes | 9800 | 0.24 | Binding ≤ 10μM |
FNTB-1-E | Protein Farnesyltransferase Beta Subunit (cluster #1 Of 3), Eukaryotic | Eukaryotes | 9800 | 0.24 | Binding ≤ 10μM |
Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
FNTB_HUMAN | P49356 | Protein Farnesyltransferase Beta Subunit, Human | 9800 | 0.24 | Binding ≤ 10μM |
FNTA_HUMAN | P49354 | Protein Farnesyltransferase/geranylgeranyltransferase Type I Alpha Subunit, Human | 9800 | 0.24 | Binding ≤ 10μM |
Description | Species |
---|---|
Apoptotic cleavage of cellular proteins | |
Inactivation, recovery and regulation of the phototransduction cascade |