| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| July 23rd, 2004 | 24 | No |
Popular Name: Homidium bromide Homidium bromide
Find On: PubMed — Wikipedia — Google
CAS Numbers: 1239-45-8 , 3546-21-2 , [1239-45-8]
1239-45-8; C11161; Ethidium bromide; Homidium bromide
2,7-Diamino-10-Ethyl-9-Phenylphenanthridinium Bromide [1239-45-8]; (Ethidium bromide)
2,7-DIAMINO-10-ETHYL-9-PHENYLPHENANTHRIDINIUM BROMIDE; [1239-45-8]
3,8-Diamino-5-ethyl-6-phenyl-phenanthridinium bromide
3,8-Diamino-5-ethyl-6-phenylphenanthridin-5-ium bromide
3,8-Diamino-5-ethyl-6-phenylphenanthridinium bromide
3,8-diamino-5-ethyl-6-phenylphenanthridinium; ETHIDIUM; ethidium cation; homidium
3546-21-2; CPD0-1938; ethidium; ethidium cation; homidium
5-ethyl-6-phenylphenanthridin-5-ium-3,8-diamine bromide
Ethidinium bromide, 3,8-Diamino-5-ethyl-6-phenylphenanthridinium bromide
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 0.30 | 8.49 | -20.4 | 4 | 3 | 1 | 56 | 314.412 | 2 | ↓ |
| Note Type | Comments | Provided By |
|---|---|---|
| Molecular_Solubility | 6.314 | Bitter DB |
| Mp [°C] | 260 - 262 | Acros Organics |
| M.P | 260-262 °C | Indofine |
| Purity | 95% | Fluorochem |
| Therapy | antiprotozoal, intercalcate with DNA | SMDC MicroSource |
| therap | antiprotozoal, intercalcates with DNA | MicroSource Spectrum |
| Notes | Assay (by dried basis) 97+% Loss on drying < 5.0%Nucleic acid intercalator; Detects as little as 10ng of DNA under short wave UV light | Apollo Scientific Bioactives |
| Melting_Point | ca 261? dec. | Alfa-Aesar |
| Melting_Point | ca 261° dec. | Alfa-Aesar |
| UniProt Database Links | DCAM_ACACA; EBRA_BACAT; EBRA_BACLD; EBRA_BACSU; EBRB_BACAT; EBRB_BACLD; EBRB_BACSU; EBR_ECOLX; EBR_PSEAI; EBR_SALTM; EMRE_ECOLI; ETBR2_BOVIN; ETBR2_HUMAN; ETBR2_MOUSE; ETBR2_RAT; FTSH_OENOE; GEP4_YEAST; GPR37_HUMAN; HMRM_HAEIN; INIA_MYCTU; MDEP_STAAU; MDF | ChEBI |
| UniProt Database Links | DCAM_ACACA; EBRA_BACAT; EBRA_BACLD; EBRA_BACSU; EBRB_BACAT; EBRB_BACLD; EBRB_BACSU; EBR_ECOLX; EBR_PSEAI; EBR_SALTM; EMRE_ECOLI; FTSH_OENOE; GEP4_YEAST; HMRM_HAEIN; INIA_MYCTU; MDEP_STAAU; MDFA_ECOLI; MDTE_ECOLI; MDTF_ECOLI; MDTK_ECOLI; MDTK_ERWAM; MDTM_E | ChEBI |
| Patent Database Links | EP1642909; EP1710256; EP1780268; EP1782838; EP1788085; EP1793001; EP1967189; US2006115848; US2007196392; US2007253900; WO2005016343; WO2007137117 | ChEBI |
| Notes | Ethidinium bromide is an intercalating dye used in the visualisation of DNA and RNA in electrophoresis gels and caesium chloride density gradients | Apollo Scientific Bioactives |
| SOLUBILITY | H2O: 10 mg/mL, opaque, strongly red | Indofine |
| H phrase | H341: Suspected of causing genetic defects | Acros Organics |
| H phrase | H341: Suspected of causing genetic defects; H330: Fatal if inhaled; H302: Harmful if swallowed | Acros Organics |
| P phrase | P310: Immediately call a POISON CENTER or doctor/physician | Acros Organics |
| P phrase | P310: Immediately call a POISON CENTER or doctor/physician; P281: Use personal protective equipment as required; P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing | Acros Organics |
| R phrase | R22: Harmful if swallowed. | Acros Organics |
| R phrase | R22: Harmful if swallowed.; R26: Very toxic by inhalation.; R68: Possible risks of irreversible effects. | Acros Organics |
| Hazard | T+: Very toxic | Acros Organics |
| Patent Database Links | US2003105066; WO2007137117 | ChEBI |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| TERT-1-E | Telomerase Reverse Transcriptase (cluster #1 Of 2), Eukaryotic | Eukaryotes | 3300 | 0.32 | Binding ≤ 10μM |
| MDTK-1-B | Multidrug Resistance Protein MdtK (cluster #1 Of 1), Bacterial | Bacteria | 9800 | 0.29 | Binding ≤ 10μM |
| Z104302-7-O | Glutamate NMDA Receptor (cluster #7 Of 7), Other | Other | 7340 | 0.30 | Binding ≤ 10μM |
| Z50643-2-O | Hepatitis C Virus (cluster #2 Of 2), Other | Other | 810 | 0.36 | Binding ≤ 10μM |
| Z50643-2-O | Hepatitis C Virus (cluster #2 Of 5), Other | Other | 600 | 0.36 | Functional ≤ 10μM |
| Z80493-1-O | SK-OV-3 (Ovarian Carcinoma Cells) (cluster #1 Of 6), Other | Other | 4500 | 0.31 | Functional ≤ 10μM |
| Z80768-1-O | CH1 (Ovarian Carcinoma Cells) (cluster #1 Of 1), Other | Other | 400 | 0.37 | Functional ≤ 10μM |
| Z81034-6-O | A2780 (Ovarian Carcinoma Cells) (cluster #6 Of 10), Other | Other | 100 | 0.41 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| Z50643 | Z50643 | Hepatitis C Virus | 810 | 0.36 | Binding ≤ 1μM |
| Z104302 | Z104302 | Glutamate NMDA Receptor | 3130 | 0.32 | Binding ≤ 10μM |
| Z50643 | Z50643 | Hepatitis C Virus | 3800 | 0.32 | Binding ≤ 10μM |
| MDTK_ECOLI | P37340 | Multidrug Resistance Protein MdtK, Ecoli | 9800 | 0.29 | Binding ≤ 10μM |
| TERT_HUMAN | O14746 | Telomerase Reverse Transcriptase, Human | 2500 | 0.33 | Binding ≤ 10μM |
| Z81034 | Z81034 | A2780 (Ovarian Carcinoma Cells) | 100 | 0.41 | Functional ≤ 10μM |
| Z80768 | Z80768 | CH1 (Ovarian Carcinoma Cells) | 400 | 0.37 | Functional ≤ 10μM |
| Z50643 | Z50643 | Hepatitis C Virus | 600 | 0.36 | Functional ≤ 10μM |
| Z80493 | Z80493 | SK-OV-3 (Ovarian Carcinoma Cells) | 400 | 0.37 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| formation of the beta-catenin:TCF transactivating complex | |
| Telomere Extension By Telomerase |
