| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| May 9th, 2008 | 14 | Yes |
Popular Name: 2-(3-chloro-2-fluorophenyl)-2,3-dihydroisothiazol-3-one 2-(3-chloro-2-fluorophenyl)-2,3-…
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CAS Number: 220862-89-5
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 2.81 | 0.97 | -14.3 | 0 | 2 | 0 | 22 | 229.663 | 1 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| KAT2B-1-E | Histone Acetyltransferase PCAF (cluster #1 Of 2), Eukaryotic | Eukaryotes | 5400 | 0.53 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| KAT2B_HUMAN | Q92831 | Histone Acetyltransferase PCAF, Human | 5400 | 0.53 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | |
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | |
| HATs acetylate histones | |
| Notch-HLH transcription pathway | |
| NOTCH1 Intracellular Domain Regulates Transcription | |
| Pre-NOTCH Transcription and Translation | |
| RNA Polymerase I Transcription Initiation | |
| YAP1- and WWTR1 (TAZ)-stimulated gene expression |
No pre-computed analogs available. Try a structural similarity search.