| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| May 16th, 2008 | 34 | No |
Popular Name: Fluticasone Propionate Fluticasone Propionate
Find On: PubMed — Wikipedia — Google
CAS Numbers: 1093258-28-6 , 80474-14-2
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 4.61 | 10.73 | -22.95 | 1 | 5 | 0 | 81 | 500.579 | 6 | ↓ |
| Note Type | Comments | Provided By |
|---|---|---|
| mechanism | . | ZereneX Building Blocks |
| MP | 275 | TCI |
| Indications | anti-inflammatory, antiasthma, hayfever | KeyOrganics Bioactives |
| biological_use | Antiinflammatory agent | IBScreen Bioactives |
| biological_use | Corticosteroid | IBScreen Bioactives ZereneX Building Blocks |
| mechanism | Inhibitor of multiple cell types (e.g., mast cells, eosinophils, basophils, lymphocytes, macrophages, and neutrophils) and | IBScreen Bioactives |
| mechanism | mediate production or secretion (e.g., histamine, eicosanoids, leukotrienes, and cytokines) | IBScreen Bioactives |
| biological_use | Used for treatment of inflammatory bowel disease, asthma and allergic rhinitis | IBScreen Bioactives |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| GCR-2-E | Glucocorticoid Receptor (cluster #2 Of 2), Eukaryotic | Eukaryotes | 1 | 0.37 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| GCR_HUMAN | P04150 | Glucocorticoid Receptor, Human | 0.5 | 0.38 | Binding ≤ 1μM |
| GCR_HUMAN | P04150 | Glucocorticoid Receptor, Human | 0.5 | 0.38 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| BMAL1:CLOCK,NPAS2 activates circadian gene expression |
