| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| June 20th, 2008 | 27 | Yes |
Popular Name: N-[6-(1-piperidyl)hexyl]-1,2,3,4-tetrahydroacridin-9-amine N-[6-(1-piperidyl)hexyl]-1,2,3,4…
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 5.91 | 13.68 | -66.85 | 3 | 3 | 2 | 31 | 367.581 | 8 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| HNMT-1-E | Histamine N-methyltransferase (cluster #1 Of 1), Eukaryotic | Eukaryotes | 21 | 0.40 | Binding ≤ 10μM |
| HRH3-1-E | Histamine H3 Receptor (cluster #1 Of 3), Eukaryotic | Eukaryotes | 2 | 0.45 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| HRH3_HUMAN | Q9Y5N1 | Histamine H3 Receptor, Human | 1.8 | 0.45 | Binding ≤ 1μM |
| HNMT_RAT | Q01984 | Histamine N-methyltransferase, Rat | 21 | 0.40 | Binding ≤ 1μM |
| HRH3_HUMAN | Q9Y5N1 | Histamine H3 Receptor, Human | 1.8 | 0.45 | Binding ≤ 10μM |
| HNMT_RAT | Q01984 | Histamine N-methyltransferase, Rat | 21 | 0.40 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| G alpha (i) signalling events | |
| Histamine receptors |
