| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| June 20th, 2008 | 16 | Yes |
Popular Name: 6-chloro-1,1-dioxo-N-propyl-4H-thieno[3,2-e][1,2,4]thiadiazin-3-amine 6-chloro-1,1-dioxo-N-propyl-4H-t…
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 2.19 | 3.37 | -16.2 | 2 | 5 | 0 | 71 | 279.774 | 3 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| ABCC8-1-E | Sulfonylurea Receptor 1 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 2270 | 0.49 | Binding ≤ 10μM |
| IRK11-1-E | Potassium Channel, Inwardly Rectifying, Subfamily J, Member 11 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 2270 | 0.49 | Binding ≤ 10μM |
| Z50597-1-O | Rattus Norvegicus (cluster #1 Of 12), Other | Other | 700 | 0.54 | Functional ≤ 10μM |
| Z80700-1-O | Beta-TC6 (Pancreatic Insulinoma Cells) (cluster #1 Of 1), Other | Other | 2400 | 0.49 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| IRK11_HUMAN | Q14654 | Potassium Channel, Inwardly Rectifying, Subfamily J, Member 11, Human | 2270 | 0.49 | Binding ≤ 10μM |
| ABCC8_HUMAN | Q09428 | Sulfonylurea Receptor 1, Human | 2270 | 0.49 | Binding ≤ 10μM |
| Z80700 | Z80700 | Beta-TC6 (Pancreatic Insulinoma Cells) | 2400 | 0.49 | Functional ≤ 10μM |
| Z50597 | Z50597 | Rattus Norvegicus | 700 | 0.54 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| ABC-family proteins mediated transport | |
| ATP sensitive Potassium channels | |
| Regulation of insulin secretion |
