In ZINC since | Heavy atoms | Benign functionality |
---|---|---|
June 21st, 2008 | 22 | Yes |
Popular Name: 1-[1-(benzenesulfonyl)indol-3-yl]-N,N-dimethyl-methanamine 1-[1-(benzenesulfonyl)indol-3-yl…
Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
---|---|---|---|---|---|---|---|---|---|---|
Ref Reference (pH 7) | 2.87 | 8.63 | -44.82 | 1 | 4 | 1 | 44 | 315.418 | 4 | ↓ |
Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
5HT6R-2-E | Serotonin 6 (5-HT6) Receptor (cluster #2 Of 2), Eukaryotic | Eukaryotes | 3 | 0.54 | Binding ≤ 10μM |
5HT6R-1-E | 5-hydroxytryptamine Receptor 6 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 880 | 0.39 | Functional ≤ 10μM |
Z80936-1-O | HEK293 (Embryonic Kidney Fibroblasts) (cluster #1 Of 4), Other | Other | 880 | 0.39 | Functional ≤ 10μM |
Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
5HT6R_HUMAN | P50406 | Serotonin 6 (5-HT6) Receptor, Human | 3 | 0.54 | Binding ≤ 1μM |
5HT6R_HUMAN | P50406 | Serotonin 6 (5-HT6) Receptor, Human | 3 | 0.54 | Binding ≤ 10μM |
Z80936 | Z80936 | HEK293 (Embryonic Kidney Fibroblasts) | 880 | 0.39 | Functional ≤ 10μM |
5HT6R_HUMAN | P50406 | Serotonin 6 (5-HT6) Receptor, Human | 800 | 0.39 | Functional ≤ 10μM |
Description | Species |
---|---|
G alpha (s) signalling events | |
Serotonin receptors |