| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| June 22nd, 2008 | 28 | No |
Popular Name: 3-aminopropyl 3-aminopropyl
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | -4.99 | -8.44 | -334.01 | 7 | 16 | -3 | 289 | 474.165 | 10 | ↓ |
| Mid Mid (pH 6-8) | -4.99 | -8.44 | -328.63 | 7 | 16 | -3 | 289 | 474.165 | 10 | ↓ |
| Mid Mid (pH 6-8) | -4.99 | -7.29 | -491.49 | 6 | 16 | -4 | 292 | 473.157 | 10 | ↓ |
| Lo Low (pH 4.5-6) | -4.99 | -9.58 | -199.44 | 8 | 16 | -2 | 286 | 475.173 | 10 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| ITPR1-1-E | Inositol 1,4,5-trisphosphate Receptor Type 1 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 1500 | 0.29 | Binding ≤ 10μM |
| ITPR3-1-E | Inositol 1,4,5-trisphosphate Receptor Type 3 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 1116 | 0.30 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| ITPR1_HUMAN | Q14643 | Inositol 1,4,5-trisphosphate Receptor Type 1, Human | 1500 | 0.29 | Binding ≤ 10μM |
| ITPR3_HUMAN | Q14573 | Inositol 1,4,5-trisphosphate Receptor Type 3, Human | 1116 | 0.30 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Antigen activates B Cell Receptor (BCR) leading to generation of second messenge | |
| Ca2+ pathway | |
| cGMP effects | |
| DAG and IP3 signaling | |
| Effects of PIP2 hydrolysis | |
| Elevation of cytosolic Ca2+ levels | |
| FCERI mediated Ca+2 mobilization | |
| Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | |
| PLC beta mediated events | |
| Regulation of insulin secretion | |
| Role of phospholipids in phagocytosis | |
| VEGFR2 mediated cell proliferation |
