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ZINC 12

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Quick Search ZINC ID or SMILES

Names
Compounds (20)
Reactome (11)
Related By:
Pathway (5)
Organism (2)
Gene (2)
Org. Clust. (0)
ChEMBL (14)
Rings (0)

Inositol 1,4,5-trisphosphate Receptor Type 3, Human (20 Compounds)

Compound Summary

Annotation Type	Substances	Purchasable	Natural	In Man
Binding ≤ 10μM	20	13	9	4
Binding ≤ 1μM	18	13	9	4
Functional ≤ 10μM	8	0	0	0

Reactome ID	Description	Species
REACT_118700	Antigen activates B Cell Receptor (BCR) leading to generation of second messenge	Homo sapiens
REACT_172761	Ca2+ pathway	Homo sapiens
REACT_111064	DAG and IP3 signaling	Homo sapiens
REACT_2202	Effects of PIP2 hydrolysis	Homo sapiens
REACT_162	Elevation of cytosolic Ca2+ levels	Homo sapiens
REACT_163834	FCERI mediated Ca+2 mobilization	Homo sapiens
REACT_18274	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	Homo sapiens
REACT_15426	PLC beta mediated events	Homo sapiens
REACT_18325	Regulation of insulin secretion	Homo sapiens
REACT_160158	Role of phospholipids in phagocytosis	Homo sapiens
REACT_228024	VEGFR2 mediated cell proliferation	Homo sapiens

Uniprot	Swissprot	Chembl	Description	Number Shared
ITPR1_HUMAN	Q14643	CHEMBL4046	Inositol 1,4,5-trisphosphate Receptor Type 1, Human	23
ITPR2_HUMAN	Q14571	CHEMBL2512	Inositol 1,4,5-trisphosphate Receptor Type 2, Human	21

Ca2+ pathway

Uniprot	Swissprot	Chembl	Description	Number Shared
ITPR1_HUMAN	Q14643	CHEMBL4046	Inositol 1,4,5-trisphosphate Receptor Type 1, Human	23
ITPR2_HUMAN	Q14571	CHEMBL2512	Inositol 1,4,5-trisphosphate Receptor Type 2, Human	21

DAG and IP3 signaling

Uniprot	Swissprot	Chembl	Description	Number Shared
ITPR1_HUMAN	Q14643	CHEMBL4046	Inositol 1,4,5-trisphosphate Receptor Type 1, Human	23
ITPR2_HUMAN	Q14571	CHEMBL2512	Inositol 1,4,5-trisphosphate Receptor Type 2, Human	21

Effects of PIP2 hydrolysis

Uniprot	Swissprot	Chembl	Description	Number Shared
ITPR1_HUMAN	Q14643	CHEMBL4046	Inositol 1,4,5-trisphosphate Receptor Type 1, Human	23
ITPR2_HUMAN	Q14571	CHEMBL2512	Inositol 1,4,5-trisphosphate Receptor Type 2, Human	21

Elevation of cytosolic Ca2+ levels

Uniprot	Swissprot	Chembl	Description	Number Shared
ITPR1_HUMAN	Q14643	CHEMBL4046	Inositol 1,4,5-trisphosphate Receptor Type 1, Human	23
ITPR2_HUMAN	Q14571	CHEMBL2512	Inositol 1,4,5-trisphosphate Receptor Type 2, Human	21

FCERI mediated Ca+2 mobilization

Uniprot	Swissprot	Chembl	Description	Number Shared
ITPR1_HUMAN	Q14643	CHEMBL4046	Inositol 1,4,5-trisphosphate Receptor Type 1, Human	23
ITPR2_HUMAN	Q14571	CHEMBL2512	Inositol 1,4,5-trisphosphate Receptor Type 2, Human	21

Glucagon-like Peptide-1 (GLP1) regulates insulin secretion

Uniprot	Swissprot	Chembl	Description	Number Shared
ITPR1_HUMAN	Q14643	CHEMBL4046	Inositol 1,4,5-trisphosphate Receptor Type 1, Human	23
ITPR2_HUMAN	Q14571	CHEMBL2512	Inositol 1,4,5-trisphosphate Receptor Type 2, Human	21

PLC beta mediated events

Uniprot	Swissprot	Chembl	Description	Number Shared
ITPR1_HUMAN	Q14643	CHEMBL4046	Inositol 1,4,5-trisphosphate Receptor Type 1, Human	23
ITPR2_HUMAN	Q14571	CHEMBL2512	Inositol 1,4,5-trisphosphate Receptor Type 2, Human	21

Regulation of insulin secretion

Uniprot	Swissprot	Chembl	Description	Number Shared
ITPR1_HUMAN	Q14643	CHEMBL4046	Inositol 1,4,5-trisphosphate Receptor Type 1, Human	23
ITPR2_HUMAN	Q14571	CHEMBL2512	Inositol 1,4,5-trisphosphate Receptor Type 2, Human	21

Role of phospholipids in phagocytosis

Uniprot	Swissprot	Chembl	Description	Number Shared
ITPR1_HUMAN	Q14643	CHEMBL4046	Inositol 1,4,5-trisphosphate Receptor Type 1, Human	23
ITPR2_HUMAN	Q14571	CHEMBL2512	Inositol 1,4,5-trisphosphate Receptor Type 2, Human	21

VEGFR2 mediated cell proliferation

Uniprot	Swissprot	Chembl	Description	Number Shared
ITPR1_HUMAN	Q14643	CHEMBL4046	Inositol 1,4,5-trisphosphate Receptor Type 1, Human	23
ITPR2_HUMAN	Q14571	CHEMBL2512	Inositol 1,4,5-trisphosphate Receptor Type 2, Human	21

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
ITPR3_BOVIN	Q8WN95	CHEMBL2853	Inositol 1,4,5-trisphosphate Receptor Type 3, Bovin	31	11	6	5
ITPR3_RAT	Q63269	CHEMBL2846	Inositol 1,4,5-trisphosphate Receptor Type 3, Rat	21	5	5	4

UniProt	Swissprot	ChEMBL	Description	Substances	Purchasable	Natural	In Man
ITPR1_HUMAN	Q14643	CHEMBL4046	Inositol 1,4,5-trisphosphate Receptor Type 1, Human	17	9	7	4
ITPR2_HUMAN	Q14571	CHEMBL2512	Inositol 1,4,5-trisphosphate Receptor Type 2, Human	13	9	7	4

Clustered By Gene (0)

Uniprot	Swissprot	Chembl	Description	Number Shared
ITPR1_HUMAN	Q14643	CHEMBL4046	Inositol 1,4,5-trisphosphate Receptor Type 1, Human	23
ITPR2_HUMAN	Q14571	CHEMBL2512	Inositol 1,4,5-trisphosphate Receptor Type 2, Human	21
ITPR1_BOVIN	Q9TU34	CHEMBL2509	Inositol 1,4,5-trisphosphate Receptor Type 1, Bovin	8
ITPR2_BOVIN	Q8WN96	CHEMBL3112	Inositol 1,4,5-trisphosphate Receptor Type 2, Bovin	8
ITPR3_BOVIN	Q8WN95	CHEMBL2853	Inositol 1,4,5-trisphosphate Receptor Type 3, Bovin	8
ITPR1_RAT	P29994	CHEMBL2804	Inositol 1,4,5-trisphosphate Receptor Type 1, Rat	5
ITPR2_RAT	P29995	CHEMBL2537	Inositol 1,4,5-trisphosphate Receptor Type 2, Rat	5
ITPR3_RAT	Q63269	CHEMBL2846	Inositol 1,4,5-trisphosphate Receptor Type 3, Rat	5
IP3KA_RAT	P17105	CHEMBL3261	Inositol-trisphosphate 3-kinase A, Rat	4
IP3KB_RAT	P42335	CHEMBL3307	Inositol-trisphosphate 3-kinase B, Rat	4
IP3KC_RAT	Q80ZG2	CHEMBL2667	Inositol 1,4,5-trisphosphate 3 Kinase C, Rat	4
P79248_PIG	P79248	CHEMBL2950	Type 1 InsP3 Receptor Isoform S2, Pig	4
PLCL1_RAT	Q62688	CHEMBL3364	Inositol 1,4,5-trisphosphate Binding Protein, Rat	4
Z50591	Z50591	CHEMBL613489	Bos Taurus	1

Synonyms
Compounds (20)
Related By:
Pathway (5)
Organism (2)
Gene (2)
ChEMBL (14)
Org. Clust. (0)
Rings (0)