| Annotation Type | Substances | Purchasable | Natural | In Man |
|---|---|---|---|---|
| Binding ≤ 10μM | 13 | 9 | 7 | 4 |
| Binding ≤ 1μM | 13 | 9 | 7 | 4 |
| Functional ≤ 10μM | 8 | 0 | 0 | 0 |
| Reactome ID | Description | Species |
|---|---|---|
| REACT_118700 | Antigen activates B Cell Receptor (BCR) leading to generation of second messenge | Homo sapiens |
| REACT_172761 | Ca2+ pathway | Homo sapiens |
| REACT_111064 | DAG and IP3 signaling | Homo sapiens |
| REACT_2202 | Effects of PIP2 hydrolysis | Homo sapiens |
| REACT_162 | Elevation of cytosolic Ca2+ levels | Homo sapiens |
| REACT_163834 | FCERI mediated Ca+2 mobilization | Homo sapiens |
| REACT_18274 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | Homo sapiens |
| REACT_15426 | PLC beta mediated events | Homo sapiens |
| REACT_18325 | Regulation of insulin secretion | Homo sapiens |
| REACT_160158 | Role of phospholipids in phagocytosis | Homo sapiens |
| REACT_228024 | VEGFR2 mediated cell proliferation | Homo sapiens |
| Uniprot | Swissprot | Chembl | Description | Number Shared |
|---|---|---|---|---|
| ITPR1_HUMAN | Q14643 | CHEMBL4046 | Inositol 1,4,5-trisphosphate Receptor Type 1, Human | 21 |
| ITPR3_HUMAN | Q14573 | CHEMBL3904 | Inositol 1,4,5-trisphosphate Receptor Type 3, Human | 21 |
| Uniprot | Swissprot | Chembl | Description | Number Shared |
|---|---|---|---|---|
| ITPR1_HUMAN | Q14643 | CHEMBL4046 | Inositol 1,4,5-trisphosphate Receptor Type 1, Human | 21 |
| ITPR3_HUMAN | Q14573 | CHEMBL3904 | Inositol 1,4,5-trisphosphate Receptor Type 3, Human | 21 |
| Uniprot | Swissprot | Chembl | Description | Number Shared |
|---|---|---|---|---|
| ITPR1_HUMAN | Q14643 | CHEMBL4046 | Inositol 1,4,5-trisphosphate Receptor Type 1, Human | 21 |
| ITPR3_HUMAN | Q14573 | CHEMBL3904 | Inositol 1,4,5-trisphosphate Receptor Type 3, Human | 21 |
| Uniprot | Swissprot | Chembl | Description | Number Shared |
|---|---|---|---|---|
| ITPR1_HUMAN | Q14643 | CHEMBL4046 | Inositol 1,4,5-trisphosphate Receptor Type 1, Human | 21 |
| ITPR3_HUMAN | Q14573 | CHEMBL3904 | Inositol 1,4,5-trisphosphate Receptor Type 3, Human | 21 |
| Uniprot | Swissprot | Chembl | Description | Number Shared |
|---|---|---|---|---|
| ITPR1_HUMAN | Q14643 | CHEMBL4046 | Inositol 1,4,5-trisphosphate Receptor Type 1, Human | 21 |
| ITPR3_HUMAN | Q14573 | CHEMBL3904 | Inositol 1,4,5-trisphosphate Receptor Type 3, Human | 21 |
| Uniprot | Swissprot | Chembl | Description | Number Shared |
|---|---|---|---|---|
| ITPR1_HUMAN | Q14643 | CHEMBL4046 | Inositol 1,4,5-trisphosphate Receptor Type 1, Human | 21 |
| ITPR3_HUMAN | Q14573 | CHEMBL3904 | Inositol 1,4,5-trisphosphate Receptor Type 3, Human | 21 |
| Uniprot | Swissprot | Chembl | Description | Number Shared |
|---|---|---|---|---|
| ITPR1_HUMAN | Q14643 | CHEMBL4046 | Inositol 1,4,5-trisphosphate Receptor Type 1, Human | 21 |
| ITPR3_HUMAN | Q14573 | CHEMBL3904 | Inositol 1,4,5-trisphosphate Receptor Type 3, Human | 21 |
| Uniprot | Swissprot | Chembl | Description | Number Shared |
|---|---|---|---|---|
| ITPR1_HUMAN | Q14643 | CHEMBL4046 | Inositol 1,4,5-trisphosphate Receptor Type 1, Human | 21 |
| ITPR3_HUMAN | Q14573 | CHEMBL3904 | Inositol 1,4,5-trisphosphate Receptor Type 3, Human | 21 |
| Uniprot | Swissprot | Chembl | Description | Number Shared |
|---|---|---|---|---|
| ITPR1_HUMAN | Q14643 | CHEMBL4046 | Inositol 1,4,5-trisphosphate Receptor Type 1, Human | 21 |
| ITPR3_HUMAN | Q14573 | CHEMBL3904 | Inositol 1,4,5-trisphosphate Receptor Type 3, Human | 21 |
| Uniprot | Swissprot | Chembl | Description | Number Shared |
|---|---|---|---|---|
| ITPR1_HUMAN | Q14643 | CHEMBL4046 | Inositol 1,4,5-trisphosphate Receptor Type 1, Human | 21 |
| ITPR3_HUMAN | Q14573 | CHEMBL3904 | Inositol 1,4,5-trisphosphate Receptor Type 3, Human | 21 |
| Uniprot | Swissprot | Chembl | Description | Number Shared |
|---|---|---|---|---|
| ITPR1_HUMAN | Q14643 | CHEMBL4046 | Inositol 1,4,5-trisphosphate Receptor Type 1, Human | 21 |
| ITPR3_HUMAN | Q14573 | CHEMBL3904 | Inositol 1,4,5-trisphosphate Receptor Type 3, Human | 21 |
| UniProt | Swissprot | ChEMBL | Description | Substances | Purchasable | Natural | In Man |
|---|---|---|---|---|---|---|---|
| ITPR2_BOVIN | Q8WN96 | CHEMBL3112 | Inositol 1,4,5-trisphosphate Receptor Type 2, Bovin | 20 | 8 | 6 | 5 |
| ITPR2_RAT | P29995 | CHEMBL2537 | Inositol 1,4,5-trisphosphate Receptor Type 2, Rat | 21 | 5 | 5 | 4 |
| UniProt | Swissprot | ChEMBL | Description | Substances | Purchasable | Natural | In Man |
|---|---|---|---|---|---|---|---|
| ITPR1_HUMAN | Q14643 | CHEMBL4046 | Inositol 1,4,5-trisphosphate Receptor Type 1, Human | 17 | 9 | 7 | 4 |
| ITPR3_HUMAN | Q14573 | CHEMBL3904 | Inositol 1,4,5-trisphosphate Receptor Type 3, Human | 20 | 13 | 9 | 4 |
| Uniprot | Swissprot | Chembl | Description | Number Shared |
|---|---|---|---|---|
| ITPR1_HUMAN | Q14643 | CHEMBL4046 | Inositol 1,4,5-trisphosphate Receptor Type 1, Human | 21 |
| ITPR3_HUMAN | Q14573 | CHEMBL3904 | Inositol 1,4,5-trisphosphate Receptor Type 3, Human | 21 |
| ITPR1_BOVIN | Q9TU34 | CHEMBL2509 | Inositol 1,4,5-trisphosphate Receptor Type 1, Bovin | 8 |
| ITPR2_BOVIN | Q8WN96 | CHEMBL3112 | Inositol 1,4,5-trisphosphate Receptor Type 2, Bovin | 8 |
| ITPR3_BOVIN | Q8WN95 | CHEMBL2853 | Inositol 1,4,5-trisphosphate Receptor Type 3, Bovin | 8 |
| ITPR1_RAT | P29994 | CHEMBL2804 | Inositol 1,4,5-trisphosphate Receptor Type 1, Rat | 5 |
| ITPR2_RAT | P29995 | CHEMBL2537 | Inositol 1,4,5-trisphosphate Receptor Type 2, Rat | 5 |
| ITPR3_RAT | Q63269 | CHEMBL2846 | Inositol 1,4,5-trisphosphate Receptor Type 3, Rat | 5 |
| IP3KA_RAT | P17105 | CHEMBL3261 | Inositol-trisphosphate 3-kinase A, Rat | 4 |
| IP3KB_RAT | P42335 | CHEMBL3307 | Inositol-trisphosphate 3-kinase B, Rat | 4 |
| IP3KC_RAT | Q80ZG2 | CHEMBL2667 | Inositol 1,4,5-trisphosphate 3 Kinase C, Rat | 4 |
| P79248_PIG | P79248 | CHEMBL2950 | Type 1 InsP3 Receptor Isoform S2, Pig | 4 |
| PLCL1_RAT | Q62688 | CHEMBL3364 | Inositol 1,4,5-trisphosphate Binding Protein, Rat | 4 |
| Z50591 | Z50591 | CHEMBL613489 | Bos Taurus | 1 |