| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| June 22nd, 2008 | 15 | Yes |
Popular Name: 6-Amino-4-oxo-1,4-dihydroquinoline-2-carboxylic acid 6-Amino-4-oxo-1,4-dihydroquinoli…
Find On: PubMed — Wikipedia — Google
CAS Number: 52980-10-6
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | -0.26 | 1.76 | -46.78 | 3 | 5 | -1 | 99 | 203.177 | 1 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| TNR16-1-E | Low Affinity Neurotrophin Receptor P75NTR (cluster #1 Of 1), Eukaryotic | Eukaryotes | 3100 | 0.51 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| TNR16_HUMAN | P08138 | Low Affinity Neurotrophin Receptor P75NTR, Human | 3100 | 0.51 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Axonal growth inhibition (RHOA activation) | |
| Axonal growth stimulation | |
| Ceramide signalling | |
| NADE modulates death signalling | |
| NF-kB is activated and signals survival | |
| NFG and proNGF binds to p75NTR | |
| NRAGE signals death through JNK | |
| NRIF signals cell death from the nucleus | |
| p75NTR negatively regulates cell cycle via SC1 | |
| p75NTR recruits signalling complexes | |
| Regulated proteolysis of p75NTR |
