| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| June 22nd, 2008 | 31 | Yes |
Popular Name: NPS ALX COMPOUND 4A DIHYDROCHLORIDE NPS ALX COMPOUND 4A DIHYDROCHLORIDE
Find On: PubMed — Wikipedia — Google
CAS Number: 299433-10-6
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 4.66 | 11.24 | -45.04 | 1 | 5 | 1 | 47 | 432.569 | 3 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| 5HT6R-2-E | Serotonin 6 (5-HT6) Receptor (cluster #2 Of 2), Eukaryotic | Eukaryotes | 1 | 0.41 | Binding ≤ 10μM |
| ADCY5-1-E | Adenylate Cyclase Type V (cluster #1 Of 1), Eukaryotic | Eukaryotes | 7 | 0.37 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| 5HT6R_HUMAN | P50406 | Serotonin 6 (5-HT6) Receptor, Human | 0.2 | 0.44 | Binding ≤ 1μM |
| 5HT6R_HUMAN | P50406 | Serotonin 6 (5-HT6) Receptor, Human | 0.2 | 0.44 | Binding ≤ 10μM |
| ADCY5_HUMAN | O95622 | Adenylate Cyclase Type V, Human | 7.2 | 0.37 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| Adenylate cyclase activating pathway | |
| Adenylate cyclase inhibitory pathway | |
| Adrenaline,noradrenaline inhibits insulin secretion | |
| G alpha (i) signalling events | |
| G alpha (s) signalling events | |
| G alpha (z) signalling events | |
| Glucagon signaling in metabolic regulation | |
| Glucagon-like Peptide-1 (GLP1) regulates insulin secretion | |
| PKA activation | |
| PKA activation in glucagon signalling | |
| Serotonin receptors | |
| Vasopressin regulates renal water homeostasis via Aquaporins |
