Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	5.56	12.86	-14.5	1	4	0	55	453.489	6	↓ MOL2 SDF SMILES Flexibase
Lo Low (pH 4.5-6)	5.56	12.65	-36.02	2	4	1	56	454.497	6	↓ MOL2 SDF SMILES Flexibase

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
MK14-1-E	MAP Kinase P38 Alpha (cluster #1 Of 3), Eukaryotic	Eukaryotes	91	0.31	Binding ≤ 10μM
Z80548-1-O	THP-1 (Acute Monocytic Leukemia Cells) (cluster #1 Of 5), Other	Other	690	0.27	Functional ≤ 10μM

ChEMBL Target Annotations
Uniprot	Swissprot	Description	Affinity (nM)	LE (kcal/mol/atom)	Type
MK14_HUMAN	Q16539	MAP Kinase P38 Alpha, Human	91	0.31	Binding ≤ 1μM
MK14_HUMAN	Q16539	MAP Kinase P38 Alpha, Human	91	0.31	Binding ≤ 10μM
Z80548	Z80548	THP-1 (Acute Monocytic Leukemia Cells)	690	0.27	Functional ≤ 10μM

Description	Species
activated TAK1 mediates p38 MAPK activation	Homo sapiens (MK14_HUMAN)
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	Homo sapiens (MK14_HUMAN)
Activation of the AP-1 family of transcription factors	Homo sapiens (MK14_HUMAN)
ADP signalling through P2Y purinoceptor 1	Homo sapiens (MK14_HUMAN)
CDO in myogenesis	Homo sapiens (MK14_HUMAN)
DSCAM interactions	Homo sapiens (MK14_HUMAN)
ERK/MAPK targets	Homo sapiens (MK14_HUMAN)
KSRP destabilizes mRNA	Homo sapiens (MK14_HUMAN)
NOD1/2 Signaling Pathway	Homo sapiens (MK14_HUMAN)
Oxidative Stress Induced Senescence	Homo sapiens (MK14_HUMAN)
p38MAPK events	Homo sapiens (MK14_HUMAN)
Platelet sensitization by LDL	Homo sapiens (MK14_HUMAN)
VEGFA-VEGFR2 Pathway	Homo sapiens (MK14_HUMAN)