Physical Representations
Type
pH range
|
xlogP
|
Des A‑Pol
Apolar desolvation
(kcal/mol)
|
Des Pol
Polar desolvation
(kcal/mol)
|
H Don
H-bond donors
|
H Acc
H-bond acceptors
|
Chg
Net charge
|
tPSA
(Ų)
|
MWT
Molecular weight
(g/mol)
|
RB
Rotatable bonds
|
DL |
Ref
Reference (pH 7)
|
4.88 |
11.35 |
-93.75 |
4 |
5 |
2 |
56 |
406.574 |
7 |
↓
|
Clustered Target Annotations
Code |
Organism Class |
Affinity (nM) |
LE (kcal/mol/atom) |
Type |
FGFR3-1-E |
Fibroblast Growth Factor Receptor 3 (cluster #1 Of 1), Eukaryotic |
Eukaryotes |
1400 |
0.27 |
Binding ≤ 10μM
|
KIT-1-E |
Stem Cell Growth Factor Receptor (cluster #1 Of 1), Eukaryotic |
Eukaryotes |
3600 |
0.25 |
Binding ≤ 10μM
|
PGFRA-1-E |
Platelet-derived Growth Factor Receptor Alpha (cluster #1 Of 2), Eukaryotic |
Eukaryotes |
2000 |
0.27 |
Binding ≤ 10μM
|
Reactome Annotations from Targets (via Uniprot)
Description |
Species |
Constitutive PI3K/AKT Signaling in Cancer |
|
Downstream signal transduction |
|
PIP3 activates AKT signaling |
|
Regulation of KIT signaling |
|
Signaling by activated point mutants of FGFR3 |
|
Signaling by FGFR mutants |
|
Signaling by FGFR3 mutants |
|
Signaling by PDGF |
|
Signaling by SCF-KIT |
|
t(4;14) translocations of FGFR3 |
|
No pre-computed analogs available. Try a structural similarity search.