In ZINC since | Heavy atoms | Benign functionality |
---|---|---|
June 24th, 2008 | 18 | Yes |
Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
---|---|---|---|---|---|---|---|---|---|---|
Ref Reference (pH 7) | 2.56 | 5.64 | -38.24 | 2 | 3 | 1 | 38 | 244.314 | 1 | ↓ |
Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
ACM1-5-E | Muscarinic Acetylcholine Receptor M1 (cluster #5 Of 5), Eukaryotic | Eukaryotes | 810 | 0.47 | Binding ≤ 10μM |
ACM2-4-E | Muscarinic Acetylcholine Receptor M2 (cluster #4 Of 6), Eukaryotic | Eukaryotes | 6900 | 0.40 | Binding ≤ 10μM |
ACM3-1-E | Muscarinic Acetylcholine Receptor M3 (cluster #1 Of 5), Eukaryotic | Eukaryotes | 6900 | 0.40 | Binding ≤ 10μM |
ACM4-1-E | Muscarinic Acetylcholine Receptor M4 (cluster #1 Of 6), Eukaryotic | Eukaryotes | 6900 | 0.40 | Binding ≤ 10μM |
ACM5-3-E | Muscarinic Acetylcholine Receptor M5 (cluster #3 Of 4), Eukaryotic | Eukaryotes | 6900 | 0.40 | Binding ≤ 10μM |
Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
ACM1_HUMAN | P11229 | Muscarinic Acetylcholine Receptor M1, Human | 810 | 0.47 | Binding ≤ 1μM |
ACM1_HUMAN | P11229 | Muscarinic Acetylcholine Receptor M1, Human | 6900 | 0.40 | Binding ≤ 10μM |
ACM2_HUMAN | P08172 | Muscarinic Acetylcholine Receptor M2, Human | 2700 | 0.43 | Binding ≤ 10μM |
ACM3_HUMAN | P20309 | Muscarinic Acetylcholine Receptor M3, Human | 4400 | 0.42 | Binding ≤ 10μM |
ACM4_HUMAN | P08173 | Muscarinic Acetylcholine Receptor M4, Human | 6900 | 0.40 | Binding ≤ 10μM |
ACM5_HUMAN | P08912 | Muscarinic Acetylcholine Receptor M5, Human | 6900 | 0.40 | Binding ≤ 10μM |
Description | Species |
---|---|
Acetylcholine regulates insulin secretion | |
G alpha (i) signalling events | |
G alpha (q) signalling events | |
Muscarinic acetylcholine receptors |