| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| June 24th, 2008 | 27 | Yes |
Popular Name: N-[3-benzyl-4-[(2S)-2-hydroxy-3-(isopropylamino)propoxy]phenyl]propanamide N-[3-benzyl-4-[(2S)-2-hydroxy-3-…
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 3.75 | 7.44 | -46.29 | 4 | 5 | 1 | 75 | 371.501 | 10 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| FDFT-4-E | Squalene Synthetase (cluster #4 Of 4), Eukaryotic | Eukaryotes | 900 | 0.31 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| FDFT_RAT | Q02769 | Squalene Synthetase, Rat | 900 | 0.31 | Binding ≤ 1μM |
| FDFT_RAT | Q02769 | Squalene Synthetase, Rat | 900 | 0.31 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Activation of gene expression by SREBF (SREBP) | |
| Cholesterol biosynthesis | |
| PPARA activates gene expression |
