| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| June 25th, 2008 | 27 | No |
Popular Name: 3-(3-pyridyl)propyl 3-(3-pyridyl)propyl
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 2.71 | 11.11 | -10.58 | 0 | 6 | 0 | 77 | 374.481 | 9 | ↓ |
| Lo Low (pH 4.5-6) | 2.71 | 11.39 | -38.38 | 1 | 6 | 1 | 78 | 375.489 | 9 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| FKB1A-1-E | FK506-binding Protein 1A (cluster #1 Of 1), Eukaryotic | Eukaryotes | 130 | 0.36 | Binding ≤ 10μM |
| FKB1A-1-E | FK506-binding Protein 1A (cluster #1 Of 1), Eukaryotic | Eukaryotes | 165 | 0.35 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| FKB1A_HUMAN | P62942 | FK506-binding Protein 1A, Human | 130 | 0.36 | Binding ≤ 1μM |
| FKB1A_HUMAN | P62942 | FK506-binding Protein 1A, Human | 130 | 0.36 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| TGF-beta receptor signaling activates SMADs | |
| TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | |
| TGFBR1 KD Mutants in Cancer | |
| TGFBR1 LBD Mutants in Cancer | |
| TGFBR2 Kinase Domain Mutants in Cancer |
