| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| August 16th, 2004 | 28 | Yes |
Popular Name: Src I1 Src I1
Find On: PubMed — Wikipedia — Google
CAS Numbers: 179248-59-0 , 179248-59-0; 179248-61-4
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 5.03 | 1.19 | -11.66 | 1 | 6 | 0 | 65 | 373.412 | 6 | ↓ |
| Note Type | Comments | Provided By |
|---|---|---|
| Indications | Src family tyrosine kinase inhibitor | KeyOrganics Bioactives |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| RIPK2-1-E | Serine/threonine-protein Kinase RIPK2 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 26 | 0.38 | Binding ≤ 10μM |
| SRC-1-E | Tyrosine-protein Kinase SRC (cluster #1 Of 3), Eukaryotic | Eukaryotes | 180 | 0.34 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| RIPK2_HUMAN | O43353 | Serine/threonine-protein Kinase RIPK2, Human | 26 | 0.38 | Binding ≤ 1μM |
| SRC_CHICK | P00523 | Tyrosine-protein Kinase SRC, Chick | 180 | 0.34 | Binding ≤ 1μM |
| RIPK2_HUMAN | O43353 | Serine/threonine-protein Kinase RIPK2, Human | 26 | 0.38 | Binding ≤ 10μM |
| SRC_CHICK | P00523 | Tyrosine-protein Kinase SRC, Chick | 180 | 0.34 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| activated TAK1 mediates p38 MAPK activation | |
| ADP signalling through P2Y purinoceptor 1 | |
| c-src mediated regulation of Cx43 function and closure of gap junctions | |
| CD28 co-stimulation | |
| CTLA4 inhibitory signaling | |
| DCC mediated attractive signaling | |
| Downstream signal transduction | |
| Downstream TCR signaling | |
| DSCAM interactions | |
| EPH-ephrin mediated repulsion of cells | |
| EPH-Ephrin signaling | |
| EPHA-mediated growth cone collapse | |
| EPHB-mediated forward signaling | |
| Ephrin signaling | |
| GAB1 signalosome | |
| GP1b-IX-V activation signalling | |
| GRB2:SOS provides linkage to MAPK signaling for Integrins | |
| Integrin alphaIIb beta3 signaling | |
| Interleukin-1 signaling | |
| JNK (c-Jun kinases) phosphorylation and activation mediated by activated human | |
| NCAM signaling for neurite out-growth | |
| Netrin mediated repulsion signals | |
| NOD1/2 Signaling Pathway | |
| p130Cas linkage to MAPK signaling for integrins | |
| p38MAPK events | |
| p75NTR recruits signalling complexes | |
| Regulation of KIT signaling | |
| Signal regulatory protein (SIRP) family interactions | |
| Signaling by EGFR | |
| Signaling by ERBB2 | |
| Signaling by SCF-KIT | |
| TAK1 activates NFkB by phosphorylation and activation of IKKs complex | |
| Thrombin signalling through proteinase activated receptors (PARs) | |
| VEGFA-VEGFR2 Pathway | |
| VEGFR2 mediated cell proliferation |
