Physical Representations
|
Type
pH range
|
xlogP
|
Des A‑Pol
Apolar desolvation
(kcal/mol)
|
Des Pol
Polar desolvation
(kcal/mol)
|
H Don
H-bond donors
|
H Acc
H-bond acceptors
|
Chg
Net charge
|
tPSA
(Ų)
|
MWT
Molecular weight
(g/mol)
|
RB
Rotatable bonds
|
DL |
|
Ref
Reference (pH 7)
|
3.75 |
1.37 |
-8.46 |
0 |
2 |
0 |
22 |
259.305 |
1 |
↓
|
Clustered Target Annotations
| Code |
Organism Class |
Affinity (nM) |
LE (kcal/mol/atom) |
Type |
|
KAT2B-1-E |
Histone Acetyltransferase PCAF (cluster #1 Of 2), Eukaryotic |
Eukaryotes |
3690 |
0.42 |
Binding ≤ 10μM |
ChEMBL Target Annotations
| Uniprot |
Swissprot |
Affinity (nM) |
LE (kcal/mol/atom) |
Type |
|
KAT2B_HUMAN |
Q92831
|
Histone Acetyltransferase PCAF, Human |
3690 |
0.42 |
Binding ≤ 10μM |
Reactome Annotations from Targets (via Uniprot)
| Description |
Species |
|
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants |
|
|
Constitutive Signaling by NOTCH1 PEST Domain Mutants |
|
|
HATs acetylate histones |
|
|
Notch-HLH transcription pathway |
|
|
NOTCH1 Intracellular Domain Regulates Transcription |
|
|
Pre-NOTCH Transcription and Translation |
|
|
RNA Polymerase I Transcription Initiation |
|
|
YAP1- and WWTR1 (TAZ)-stimulated gene expression |
|
No pre-computed analogs available. Try a structural similarity search.
