| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| November 28th, 2005 | 20 | No |
Popular Name: 3-(4-Isopropylbenzylidenyl)indolin-2-one 3-(4-Isopropylbenzylidenyl)indol…
Find On: PubMed — Wikipedia — Google
CAS Numbers: 186611-55-2 , 210303-05-2
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 4.64 | 8.67 | -8.19 | 1 | 2 | 0 | 33 | 263.34 | 2 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| IGF1R-1-E | Insulin-like Growth Factor 1 Receptor (cluster #1 Of 2), Eukaryotic | Eukaryotes | 10000 | 0.35 | Binding ≤ 10μM |
| VGFR1-1-E | Vascular Endothelial Growth Factor Receptor 1 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 5200 | 0.37 | Binding ≤ 10μM |
| AMPC-1-B | Beta-lactamase (cluster #1 Of 6), Bacterial | Bacteria | 7000 | 0.36 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| AMPC_ECOLI | P00811 | Beta-lactamase, Ecoli | 3000 | 0.39 | Binding ≤ 10μM |
| IGF1R_HUMAN | P08069 | Insulin-like Growth Factor I Receptor, Human | 10000 | 0.35 | Binding ≤ 10μM |
| VGFR1_MOUSE | P35969 | Vascular Endothelial Growth Factor Receptor 1, Mouse | 5200 | 0.37 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| IRS-related events triggered by IGF1R | |
| Neurophilin interactions with VEGF and VEGFR | |
| SHC-related events triggered by IGF1R | |
| Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | |
| VEGF binds to VEGFR leading to receptor dimerization |
