| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| August 19th, 2004 | 34 | Yes |
Popular Name: KI8751 KI8751
Find On: PubMed — Wikipedia — Google
CAS Numbers: 228559-41-9 , [228559-41-9]
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 5.10 | 8.52 | -11.05 | 2 | 7 | 0 | 82 | 469.419 | 6 | ↓ |
| Note Type | Comments | Provided By |
|---|---|---|
| Target | VEGFR, c-Kit, PDGFR | Selleck Chemicals |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| FGFR2-1-E | Fibroblast Growth Factor Receptor 2 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 170 | 0.28 | Binding ≤ 10μM |
| KIT-1-E | Stem Cell Growth Factor Receptor (cluster #1 Of 1), Eukaryotic | Eukaryotes | 40 | 0.30 | Binding ≤ 10μM |
| PGFRA-2-E | Platelet-derived Growth Factor Receptor Alpha (cluster #2 Of 2), Eukaryotic | Eukaryotes | 67 | 0.30 | Binding ≤ 10μM |
| VGFR2-1-E | Vascular Endothelial Growth Factor Receptor 2 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 4 | 0.35 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| FGFR2_HUMAN | P21802 | Fibroblast Growth Factor Receptor 2, Human | 170 | 0.28 | Binding ≤ 1μM |
| PGFRA_HUMAN | P16234 | Platelet-derived Growth Factor Receptor Alpha, Human | 67 | 0.30 | Binding ≤ 1μM |
| KIT_HUMAN | P10721 | Stem Cell Growth Factor Receptor, Human | 40 | 0.30 | Binding ≤ 1μM |
| VGFR2_MOUSE | P35918 | Vascular Endothelial Growth Factor Receptor 2, Mouse | 0.9 | 0.37 | Binding ≤ 1μM |
| VGFR2_HUMAN | P35968 | Vascular Endothelial Growth Factor Receptor 2, Human | 0.9 | 0.37 | Binding ≤ 1μM |
| FGFR2_HUMAN | P21802 | Fibroblast Growth Factor Receptor 2, Human | 170 | 0.28 | Binding ≤ 10μM |
| PGFRA_HUMAN | P16234 | Platelet-derived Growth Factor Receptor Alpha, Human | 67 | 0.30 | Binding ≤ 10μM |
| KIT_HUMAN | P10721 | Stem Cell Growth Factor Receptor, Human | 40 | 0.30 | Binding ≤ 10μM |
| VGFR2_HUMAN | P35968 | Vascular Endothelial Growth Factor Receptor 2, Human | 0.9 | 0.37 | Binding ≤ 10μM |
| VGFR2_MOUSE | P35918 | Vascular Endothelial Growth Factor Receptor 2, Mouse | 0.9 | 0.37 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Activated point mutants of FGFR2 | |
| Constitutive PI3K/AKT Signaling in Cancer | |
| Downstream signal transduction | |
| EPHA-mediated growth cone collapse | |
| Integrin cell surface interactions | |
| Neurophilin interactions with VEGF and VEGFR | |
| PIP3 activates AKT signaling | |
| Regulation of KIT signaling | |
| Signaling by FGFR mutants | |
| Signaling by FGFR2 amplification mutants | |
| Signaling by PDGF | |
| Signaling by SCF-KIT | |
| VEGF binds to VEGFR leading to receptor dimerization | |
| VEGFA-VEGFR2 Pathway | |
| VEGFR2 mediated cell proliferation |
