UCSF

ZINC14985115

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Substance Information

In ZINC since Heavy atoms Benign functionality
July 18th, 2008 10 Yes

Popular Name: 5-ethyl-1H-pyrazole-3-carboxylic acid 5-ethyl-1H-pyrazole-3-carboxylic…

Find On: PubMed — Wikipedia — Google

CAS Number: 4027-59-2

Download: MOL2 SDF SMILES Flexibase

Physical Representations

Type pH range xlogP Des A‑Pol Apolar desolvation (kcal/mol) Des Pol Polar desolvation (kcal/mol) H Don H-bond donors H Acc H-bond acceptors Chg Net charge tPSA (Ų) MWT Molecular weight (g/mol) RB Rotatable bonds DL
Ref Reference (pH 7) 0.92 1.9 -43.06 1 4 -1 69 139.134 2 ↓

Vendor Notes

Note Type Comments Provided By
MP 191 - 193 Enamine Building Blocks
MP 191...193 Enamine Building Blocks
purity 9.500000000000000e+001 Enamine Building Blocks Enamine Building Blocks
Purity 95% Fluorochem
PUBCHEM_PATENT_ID EP0977756A1; EP0994115A2; EP0994115A3; EP0995750A1; WO1998049166A1; WO1999054333A1 IBM Patent Data
Warnings IRRITANT Matrix Scientific

Activity (Go SEA)

Clustered Target Annotations
Code Description Organism Class Affinity (nM) LE (kcal/mol/atom) Type
HCAR2-2-E HM74 Nicotinic Acid GPCR (cluster #2 Of 3), Eukaryotic Eukaryotes 800 0.85 Functional ≤ 10μM
ChEMBL Target Annotations
Uniprot Swissprot Description Affinity (nM) LE (kcal/mol/atom) Type
HCAR2_HUMAN Q8TDS4 Nicotinic Acid Receptor 1, Human 800 0.85 Functional ≤ 10μM

Reactome Annotations from Targets (via Uniprot)

Description Species
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
Hydroxycarboxylic acid-binding receptors

Analogs ( Draw Identity 99% 90% 80% 70% )