| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| July 26th, 2008 | 29 | No |
Popular Name: 7-Methylguanosine 5'-diphosphate 7-Methylguanosine 5'-diphosphate
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CAS Number: 104809-16-7
104809-16-7; 7-Methylguanosine 5'-diphosphate; C20183
7-methyl-GDP(2-); 7-methylguanosine 5'-diphosphate dianion; N(7)-methylguanosine 5'-diphosphate
7-Methylguanosine 5'-diphosphate sodium salt
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | -5.43 | -0.86 | -226.24 | 5 | 16 | -2 | 252 | 455.213 | 6 | ↓ |
| Hi High (pH 8-9.5) | -5.31 | -2.89 | -253.57 | 4 | 16 | -3 | 255 | 454.205 | 6 | ↓ |
| Mid Mid (pH 6-8) | -5.43 | -2.02 | -120.2 | 6 | 16 | -1 | 249 | 456.221 | 6 | ↓ |
| Note Type | Comments | Provided By |
|---|---|---|
| UniProt Database Links | DCP2_ARATH; DCP2_HUMAN; DCP2_MOUSE; DCP2_PONAB; NUD16_BOVIN; NUD16_HOMVI; NUD16_HUMAN; NUD16_MOUSE; NUD16_SHEEP; NUD16_XENLA | ChEBI |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| IF4E-1-E | Eukaryotic Translation Initiation Factor 4E (cluster #1 Of 1), Eukaryotic | Eukaryotes | 45 | 0.35 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| IF4E_MOUSE | P63073 | Eukaryotic Translation Initiation Factor 4E, Mouse | 45 | 0.35 | Binding ≤ 1μM |
| IF4E_MOUSE | P63073 | Eukaryotic Translation Initiation Factor 4E, Mouse | 45 | 0.35 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Activation of the mRNA upon binding of the cap-binding complex and eIFs, and sub | |
| Deadenylation of mRNA | |
| GTP hydrolysis and joining of the 60S ribosomal subunit | |
| ISG15 antiviral mechanism | |
| L13a-mediated translational silencing of Ceruloplasmin expression | |
| Release of eIF4E | |
| Ribosomal scanning and start codon recognition | |
| Translation initiation complex formation | |
| Transport of Mature mRNA derived from an Intron-Containing Transcript | |
| Transport of Mature mRNA Derived from an Intronless Transcript | |
| Transport of the SLBP Dependant Mature mRNA | |
| Transport of the SLBP independent Mature mRNA |
