| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| October 7th, 2004 | 28 | Yes |
Popular Name: 2-Demethylthiocolchicine 2-Demethylthiocolchicine
Find On: PubMed — Wikipedia — Google
CAS Number: 87424-26-8
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 1.89 | -0.72 | -19.94 | 2 | 6 | 0 | 84 | 401.484 | 4 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| TBB1-1-E | Tubulin Beta-1 Chain (cluster #1 Of 2), Eukaryotic | Eukaryotes | 2000 | 0.28 | Binding ≤ 10μM |
| TBB3-1-E | Tubulin Beta-3 Chain (cluster #1 Of 1), Eukaryotic | Eukaryotes | 2000 | 0.28 | Binding ≤ 10μM |
| TBB4A-1-E | Tubulin Beta-4 Chain (cluster #1 Of 1), Eukaryotic | Eukaryotes | 2000 | 0.28 | Binding ≤ 10μM |
| TBB4B-1-E | Tubulin Beta-2 Chain (cluster #1 Of 1), Eukaryotic | Eukaryotes | 2000 | 0.28 | Binding ≤ 10μM |
| TBB8-1-E | Tubulin Beta-8 Chain (cluster #1 Of 1), Eukaryotic | Eukaryotes | 2000 | 0.28 | Binding ≤ 10μM |
| Z50607-1-O | Human Immunodeficiency Virus 1 (cluster #1 Of 10), Other | Other | 52 | 0.36 | Functional ≤ 10μM |
| Z80897-1-O | H9 (T-lymphoid Cells) (cluster #1 Of 2), Other | Other | 47 | 0.37 | ADME/T ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| TBB1_HUMAN | Q9H4B7 | Tubulin Beta-1 Chain, Human | 1500 | 0.29 | Binding ≤ 10μM |
| TBB4B_HUMAN | P68371 | Tubulin Beta-2 Chain, Human | 2000 | 0.28 | Binding ≤ 10μM |
| TBB3_HUMAN | Q13509 | Tubulin Beta-3 Chain, Human | 2000 | 0.28 | Binding ≤ 10μM |
| TBB4A_HUMAN | P04350 | Tubulin Beta-4 Chain, Human | 2000 | 0.28 | Binding ≤ 10μM |
| TBB8_HUMAN | Q3ZCM7 | Tubulin Beta-8 Chain, Human | 2000 | 0.28 | Binding ≤ 10μM |
| Z50607 | Z50607 | Human Immunodeficiency Virus 1 | 52 | 0.36 | Functional ≤ 10μM |
| Z80897 | Z80897 | H9 (T-lymphoid Cells) | 47 | 0.37 | ADME/T ≤ 10μM |
| Description | Species |
|---|---|
| Formation of tubulin folding intermediates by CCT/TriC | |
| Gap junction assembly | |
| Kinesins | |
| Loss of Nlp from mitotic centrosomes | |
| Loss of proteins required for interphase microtubule organization from the ce | |
| MHC class II antigen presentation | |
| Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane | |
| Mitotic Prometaphase | |
| Post-chaperonin tubulin folding pathway | |
| Prefoldin mediated transfer of substrate to CCT/TriC | |
| Recruitment of mitotic centrosome proteins and complexes | |
| Recruitment of NuMA to mitotic centrosomes | |
| Recycling pathway of L1 | |
| Regulation of PLK1 Activity at G2/M Transition | |
| Resolution of Sister Chromatid Cohesion | |
| Separation of Sister Chromatids | |
| Translocation of GLUT4 to the plasma membrane |
