| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| October 7th, 2004 | 20 | No |
Popular Name: MEKInhibitorII MEKInhibitorII
Find On: PubMed — Wikipedia — Google
CAS Number: 623163-52-0
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 0.42 | 1.46 | -16.02 | 0 | 5 | 0 | 71 | 289.674 | 1 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| M3K8-1-E | Mitogen-activated Protein Kinase Kinase Kinase 8 (cluster #1 Of 1), Eukaryotic | Eukaryotes | 50 | 0.51 | Binding ≤ 10μM |
| MP2K1-3-E | Dual Specificity Mitogen-activated Protein Kinase Kinase 1 (cluster #3 Of 4), Eukaryotic | Eukaryotes | 380 | 0.45 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| MP2K1_HUMAN | Q02750 | Dual Specificity Mitogen-activated Protein Kinase Kinase 1, Human | 380 | 0.45 | Binding ≤ 1μM |
| M3K8_HUMAN | P41279 | Mitogen-activated Protein Kinase Kinase Kinase 8, Human | 50 | 0.51 | Binding ≤ 1μM |
| MP2K1_HUMAN | Q02750 | Dual Specificity Mitogen-activated Protein Kinase Kinase 1, Human | 380 | 0.45 | Binding ≤ 10μM |
| M3K8_HUMAN | P41279 | Mitogen-activated Protein Kinase Kinase Kinase 8, Human | 50 | 0.51 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| CD28 dependent PI3K/Akt signaling | |
| ERK1 activation | |
| Interleukin-1 signaling | |
| MEK activation | |
| RAF phosphorylates MEK | |
| Signal transduction by L1 | |
| Signaling by FGFR | |
| Uptake and function of anthrax toxins |
