| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| December 30th, 2008 | 37 | No |
None
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 6.64 | 13.05 | -42.41 | 2 | 6 | 1 | 66 | 533.483 | 6 | ↓ |
| Mid Mid (pH 6-8) | 6.64 | 12.98 | -45.51 | 2 | 6 | 1 | 66 | 533.483 | 6 | ↓ |
| Mid Mid (pH 6-8) | 6.64 | 10.58 | -8.53 | 1 | 6 | 0 | 64 | 532.475 | 6 | ↓ |
| Lo Low (pH 4.5-6) | 6.64 | 13.45 | -97.09 | 3 | 6 | 2 | 67 | 534.491 | 6 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| SRC-1-E | Tyrosine-protein Kinase SRC (cluster #1 Of 3), Eukaryotic | Eukaryotes | 5 | 0.31 | Binding ≤ 10μM |
| FYN-1-E | Tyrosine-protein Kinase FYN (cluster #1 Of 1), Eukaryotic | Eukaryotes | 830 | 0.23 | Functional ≤ 10μM |
| SRC-1-E | Tyrosine-protein Kinase SRC (cluster #1 Of 1), Eukaryotic | Eukaryotes | 390 | 0.24 | Functional ≤ 10μM |
| Z80416-1-O | Rat1 (Fibroblast Cells) (cluster #1 Of 1), Other | Other | 390 | 0.24 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| SRC_HUMAN | P12931 | Tyrosine-protein Kinase SRC, Human | 3.8 | 0.32 | Binding ≤ 1μM |
| SRC_HUMAN | P12931 | Tyrosine-protein Kinase SRC, Human | 3.8 | 0.32 | Binding ≤ 10μM |
| Z80416 | Z80416 | Rat1 (Fibroblast Cells) | 390 | 0.24 | Functional ≤ 10μM |
| FYN_HUMAN | P06241 | Tyrosine-protein Kinase FYN, Human | 830 | 0.23 | Functional ≤ 10μM |
| SRC_HUMAN | P12931 | Tyrosine-protein Kinase SRC, Human | 390 | 0.24 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| Antigen activates B Cell Receptor (BCR) leading to generation of second messenge | |
| CD28 co-stimulation | |
| CD28 dependent PI3K/Akt signaling | |
| CD28 dependent Vav1 pathway | |
| Cell surface interactions at the vascular wall | |
| Constitutive PI3K/AKT Signaling in Cancer | |
| CRMPs in Sema3A signaling | |
| CTLA4 inhibitory signaling | |
| DAP12 signaling | |
| DCC mediated attractive signaling | |
| EPH-ephrin mediated repulsion of cells | |
| EPH-Ephrin signaling | |
| EPHA-mediated growth cone collapse | |
| EPHB-mediated forward signaling | |
| Ephrin signaling | |
| FCGR activation | |
| GPVI-mediated activation cascade | |
| NCAM signaling for neurite out-growth | |
| Nef and signal transduction | |
| Nephrin interactions | |
| Netrin mediated repulsion signals | |
| PECAM1 interactions | |
| PIP3 activates AKT signaling | |
| Platelet Adhesion to exposed collagen | |
| Regulation of KIT signaling | |
| Regulation of signaling by CBL | |
| Role of LAT2/NTAL/LAB on calcium mobilization | |
| Sema3A PAK dependent Axon repulsion | |
| SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion | |
| Signaling by ERBB2 | |
| Signaling by SCF-KIT | |
| VEGFA-VEGFR2 Pathway |
![Phenyl-[7-[4-(piperazinomethyl)phenyl]-4-quinolyl]amine](http://zinc12.docking.org/img/rings/138447.gif)
