| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| February 8th, 2009 | 13 | No |
Popular Name: (1R,2S,5S,6S)-2-amino-4-thiabicyclo[3.1.0]hexane-2,6-dicarboxylic (1R,2S,5S,6S)-2-amino-4-thiabicy…
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | -2.49 | 1.42 | -91.74 | 3 | 5 | -1 | 108 | 202.211 | 2 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| GRM2-1-E | Metabotropic Glutamate Receptor 2 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 4 | 0.90 | Functional ≤ 10μM |
| GRM3-1-E | Metabotropic Glutamate Receptor 3 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 8 | 0.87 | Functional ≤ 10μM |
| GRM6-1-E | Metabotropic Glutamate Receptor 6 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 2400 | 0.61 | Functional ≤ 10μM |
| GRM8-1-E | Metabotropic Glutamate Receptor 8 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 7300 | 0.55 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| GRM2_HUMAN | Q14416 | Metabotropic Glutamate Receptor 2, Human | 3.9 | 0.91 | Functional ≤ 10μM |
| GRM3_HUMAN | Q14832 | Metabotropic Glutamate Receptor 3, Human | 7.6 | 0.87 | Functional ≤ 10μM |
| GRM6_HUMAN | O15303 | Metabotropic Glutamate Receptor 6, Human | 2400 | 0.61 | Functional ≤ 10μM |
| GRM8_HUMAN | O00222 | Metabotropic Glutamate Receptor 8, Human | 7300 | 0.55 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| Class C/3 (Metabotropic glutamate/pheromone receptors) | |
| G alpha (i) signalling events |
