In ZINC since | Heavy atoms | Benign functionality |
---|---|---|
February 8th, 2009 | 33 | Yes |
Popular Name: (2-chlorophenyl)-[(3S,4S)-3-phenyl-4-[(4-phenyl-1-piperidyl)methyl]pyrrolidin-1-yl]methanone (2-chlorophenyl)-[(3S,4S)-3-phen…
Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
---|---|---|---|---|---|---|---|---|---|---|
Ref Reference (pH 7) | 6.33 | 17.28 | -55.13 | 1 | 3 | 1 | 25 | 460.041 | 5 | ↓ |
Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
CCR5-1-E | C-C Chemokine Receptor Type 5 (cluster #1 Of 4), Eukaryotic | Eukaryotes | 52 | 0.31 | Binding ≤ 10μM |
Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
CCR5_HUMAN | P51681 | C-C Chemokine Receptor Type 5, Human | 52 | 0.31 | Binding ≤ 1μM |
CCR5_HUMAN | P51681 | C-C Chemokine Receptor Type 5, Human | 52 | 0.31 | Binding ≤ 10μM |
Description | Species |
---|---|
Binding and entry of HIV virion | |
Chemokine receptors bind chemokines | |
G alpha (i) signalling events |