| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| February 18th, 2009 | 33 | Yes |
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 3.36 | 6.35 | -122.37 | 8 | 7 | 2 | 123 | 464.695 | 20 | ↓ |
| Hi High (pH 8-9.5) | 3.36 | 5.98 | -52.87 | 7 | 7 | 1 | 121 | 463.687 | 20 | ↓ |
| Hi High (pH 8-9.5) | 3.36 | 4.94 | -56.33 | 7 | 7 | 1 | 118 | 463.687 | 20 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| GRIA1-4-E | Glutamate Receptor Ionotropic, AMPA 1 (cluster #4 Of 4), Eukaryotic | Eukaryotes | 68 | 0.30 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| GRIA1_HUMAN | P42261 | Glutamate Receptor Ionotropic, AMPA 1, Human | 1000 | 0.25 | Binding ≤ 1μM |
| GRIA1_HUMAN | P42261 | Glutamate Receptor Ionotropic, AMPA 1, Human | 1000 | 0.25 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Activation of AMPA receptors | |
| Trafficking of AMPA receptors | |
| Trafficking of GluR2-containing AMPA receptors | |
| Unblocking of NMDA receptor, glutamate binding and activation |
