| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| February 21st, 2009 | 30 | No |
Popular Name: 4-[N-allyloxy-C-(1,1,4,4,7-pentamethyltetralin-6-yl)carbonimidoyl]benzoic 4-[N-allyloxy-C-(1,1,4,4,7-penta…
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 6.96 | 13.85 | -49.84 | 0 | 4 | -1 | 62 | 404.53 | 6 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| RXRA-1-E | Retinoid X Receptor Alpha (cluster #1 Of 1), Eukaryotic | Eukaryotes | 7 | 0.38 | Binding ≤ 10μM |
| RXRB-1-E | Retinoid X Receptor Beta (cluster #1 Of 2), Eukaryotic | Eukaryotes | 15 | 0.37 | Binding ≤ 10μM |
| RXRG-1-E | Retinoid X Receptor Gamma (cluster #1 Of 1), Eukaryotic | Eukaryotes | 80 | 0.33 | Binding ≤ 10μM |
| RXRA-1-E | Retinoid X Receptor Alpha (cluster #1 Of 1), Eukaryotic | Eukaryotes | 6 | 0.38 | Functional ≤ 10μM |
| RXRB-1-E | Retinoid X Receptor Beta (cluster #1 Of 1), Eukaryotic | Eukaryotes | 18 | 0.36 | Functional ≤ 10μM |
| RXRG-1-E | Retinoid X Receptor Gamma (cluster #1 Of 2), Eukaryotic | Eukaryotes | 7 | 0.38 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| RXRA_HUMAN | P19793 | Retinoid X Receptor Alpha, Human | 7 | 0.38 | Binding ≤ 1μM |
| RXRB_HUMAN | P28702 | Retinoid X Receptor Beta, Human | 15 | 0.37 | Binding ≤ 1μM |
| RXRG_HUMAN | P48443 | Retinoid X Receptor Gamma, Human | 80 | 0.33 | Binding ≤ 1μM |
| RXRA_HUMAN | P19793 | Retinoid X Receptor Alpha, Human | 7 | 0.38 | Binding ≤ 10μM |
| RXRB_HUMAN | P28702 | Retinoid X Receptor Beta, Human | 15 | 0.37 | Binding ≤ 10μM |
| RXRG_HUMAN | P48443 | Retinoid X Receptor Gamma, Human | 80 | 0.33 | Binding ≤ 10μM |
| RXRA_HUMAN | P19793 | Retinoid X Receptor Alpha, Human | 6 | 0.38 | Functional ≤ 10μM |
| RXRB_HUMAN | P28702 | Retinoid X Receptor Beta, Human | 18 | 0.36 | Functional ≤ 10μM |
| RXRG_HUMAN | P48443 | Retinoid X Receptor Gamma, Human | 7 | 0.38 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| Activation of gene expression by SREBF (SREBP) | |
| BMAL1:CLOCK,NPAS2 activates circadian gene expression | |
| Circadian Clock | |
| Endogenous sterols | |
| Import of palmitoyl-CoA into the mitochondrial matrix | |
| Nuclear Receptor transcription pathway | |
| PPARA activates gene expression | |
| Recycling of bile acids and salts | |
| Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alp | |
| Regulation of pyruvate dehydrogenase (PDH) complex | |
| REV-ERBA represses gene expression | |
| RORA activates circadian gene expression | |
| Synthesis of bile acids and bile salts | |
| Synthesis of bile acids and bile salts via 27-hydroxycholesterol | |
| Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | |
| Transcriptional activation of mitochondrial biogenesis | |
| Transcriptional regulation of white adipocyte differentiation | |
| YAP1- and WWTR1 (TAZ)-stimulated gene expression |
