| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| February 28th, 2009 | 23 | No |
Popular Name: N-[4-[2-(hydroxyamino)-2-oxo-ethyl]thiazol-2-yl]-4-oxo-4-phenyl-butanamide N-[4-[2-(hydroxyamino)-2-oxo-eth…
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 1.07 | 3.89 | -27.19 | 3 | 7 | 0 | 108 | 333.369 | 7 | ↓ |
| Hi High (pH 8-9.5) | 1.07 | 5.14 | -65.91 | 2 | 7 | -1 | 111 | 332.361 | 7 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| PDE5A-1-E | Phosphodiesterase 5A (cluster #1 Of 2), Eukaryotic | Eukaryotes | 4520 | 0.33 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| PDE5A_HUMAN | O76074 | Phosphodiesterase 5A, Human | 4520 | 0.33 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| cGMP effects |
