| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| March 1st, 2009 | 19 | No |
Popular Name: 2-[[4-(trifluoromethyl)phenyl]sulfonylamino]ethanehydroxamic 2-[[4-(trifluoromethyl)phenyl]su…
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 0.69 | -1.08 | -19.31 | 3 | 6 | 0 | 95 | 298.242 | 5 | ↓ |
| Hi High (pH 8-9.5) | 0.69 | 0.14 | -53.87 | 2 | 6 | -1 | 98 | 297.234 | 5 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| MMP1-1-E | Matrix Metalloproteinase-1 (cluster #1 Of 2), Eukaryotic | Eukaryotes | 3 | 0.63 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| MMP1_HUMAN | P03956 | Matrix Metalloproteinase-1, Human | 3 | 0.63 | Binding ≤ 1μM |
| MMP1_HUMAN | P03956 | Matrix Metalloproteinase-1, Human | 3 | 0.63 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Activation of Matrix Metalloproteinases | |
| Basigin interactions | |
| Collagen degradation | |
| Degradation of the extracellular matrix | |
| Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l |
