| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| March 1st, 2009 | 18 | Yes |
Popular Name: DNC005951 DNC005951
None
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 1.39 | 0.45 | -13.46 | 1 | 5 | 0 | 63 | 247.25 | 1 | ↓ |
| Hi High (pH 8-9.5) | 1.65 | 1.24 | -41.4 | 0 | 5 | -1 | 66 | 246.242 | 1 | ↓ |
| Mid Mid (pH 6-8) | -2.20 | -0.65 | -35.35 | 2 | 5 | 1 | 66 | 248.258 | 0 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| PRKDC-1-E | DNA-dependent Protein Kinase (cluster #1 Of 1), Eukaryotic | Eukaryotes | 450 | 0.49 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| PRKDC_HUMAN | P78527 | DNA-dependent Protein Kinase, Human | 450 | 0.49 | Binding ≤ 1μM |
| PRKDC_HUMAN | P78527 | DNA-dependent Protein Kinase, Human | 450 | 0.49 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Cytosolic sensors of pathogen-associated DNA | |
| IRF3-mediated induction of type I IFN | |
| Nonhomologous End-joining (NHEJ) | |
| Processing of DNA ends prior to end rejoining |
