| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| March 10th, 2009 | 36 | Yes |
Popular Name: 3,4,5-Trimethoxy-N-(2-(3-(piperazin-1-ylmethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)benzamide 3,4,5-Trimethoxy-N-(2-(3-(pipera…
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CAS Numbers: 925432-73-1 , N/A
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 2.52 | 8.98 | -60.4 | 3 | 9 | 1 | 94 | 508.624 | 8 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| SIRT1-1-E | NAD-dependent Deacetylase Sirtuin 1 (cluster #1 Of 3), Eukaryotic | Eukaryotes | 2900 | 0.22 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| SIRT1_HUMAN | Q96EB6 | NAD-dependent Deacetylase Sirtuin 1, Human | 2900 | 0.22 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Regulation of HSF1-mediated heat shock response | |
| SIRT1 negatively regulates rRNA Expression |
