In ZINC since | Heavy atoms | Benign functionality |
---|---|---|
March 12th, 2009 | 20 | Yes |
Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
---|---|---|---|---|---|---|---|---|---|---|
Ref Reference (pH 7) | 3.06 | 8.38 | -46.79 | 0 | 4 | -1 | 73 | 266.276 | 5 | ↓ |
Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
MMP2-2-E | 72 KDa Type IV Collagenase (cluster #2 Of 3), Eukaryotic | Eukaryotes | 8000 | 0.36 | Binding ≤ 10μM |
Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
---|---|---|---|---|---|
MMP2_HUMAN | P08253 | Matrix Metalloproteinase-2, Human | 8000 | 0.36 | Binding ≤ 10μM |
Description | Species |
---|---|
Activation of Matrix Metalloproteinases | |
Collagen degradation | |
Degradation of the extracellular matrix | |
EPH-ephrin mediated repulsion of cells | |
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-l |