| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| March 14th, 2009 | 25 | Yes |
Popular Name: 5-[2-(cyclopropylmethoxy)phenyl]-1-methyl-3-propyl-pyrazolo[4,3-d]pyrimidin-7-ol 5-[2-(cyclopropylmethoxy)phenyl]…
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 3.83 | 8.52 | -10.58 | 1 | 6 | 0 | 73 | 338.411 | 6 | ↓ |
| Mid Mid (pH 6-8) | 4.28 | 7.06 | -55.38 | 0 | 6 | -1 | 76 | 337.403 | 6 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| PDE5A-1-E | Phosphodiesterase 5A (cluster #1 Of 2), Eukaryotic | Eukaryotes | 960 | 0.34 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| PDE5A_HUMAN | O76074 | Phosphodiesterase 5A, Human | 954.992586 | 0.34 | Binding ≤ 1μM |
| PDE5A_HUMAN | O76074 | Phosphodiesterase 5A, Human | 954.992586 | 0.34 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| cGMP effects |
