| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| April 19th, 2009 | 27 | No |
Popular Name: 2-(2-amino-6-oxo-3H-purin-9-yl)ethoxymethyl-[hydroxy(phosphonooxy)phosphoryl]oxy-phosphinic 2-(2-amino-6-oxo-3H-purin-9-yl)e…
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | -4.15 | 1.23 | -354.02 | 3 | 16 | -4 | 261 | 445.114 | 9 | ↓ |
| Mid Mid (pH 6-8) | -4.15 | 0.07 | -220.02 | 4 | 16 | -3 | 258 | 446.122 | 9 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| DPOLA-1-E | DNA Polymerase Alpha Subunit (cluster #1 Of 2), Eukaryotic | Eukaryotes | 2500 | 0.29 | Binding ≤ 10μM |
| DPOLB-1-E | DNA Polymerase Beta (cluster #1 Of 3), Eukaryotic | Eukaryotes | 1600 | 0.30 | Binding ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| DPOLA_HUMAN | P09884 | DNA Polymerase Alpha Subunit, Human | 2500 | 0.29 | Binding ≤ 10μM |
| DPOLB_HUMAN | P06746 | DNA Polymerase Beta, Human | 1600 | 0.30 | Binding ≤ 10μM |
| Description | Species |
|---|---|
| Activation of the pre-replicative complex | |
| Base-free sugar-phosphate removal via the single-nucleotide replacement pathway | |
| DNA replication initiation | |
| E2F mediated regulation of DNA replication | |
| G1/S-Specific Transcription | |
| Inhibition of replication initiation of damaged DNA by RB1/E2F1 | |
| Leading Strand Synthesis | |
| Polymerase switching | |
| Polymerase switching on the C-strand of the telomere | |
| Processive synthesis on the lagging strand | |
| Removal of DNA patch containing abasic residue | |
| Removal of the Flap Intermediate | |
| Resolution of AP sites via the single-nucleotide replacement pathway | |
| Telomere C-strand synthesis initiation |
