Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Ref Reference (pH 7)	5.64	13.4	-57.6	1	8	0	93	510.631	12	↓ MOL2 SDF SMILES Flexibase
Hi High (pH 8-9.5)	5.64	11.89	-56.97	0	8	-1	91	509.623	12	↓ MOL2 SDF SMILES Flexibase

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
EDNRA-1-E	Endothelin Receptor ET-A (cluster #1 Of 3), Eukaryotic	Eukaryotes	0	0.00	Binding ≤ 10μM
EDNRB-1-E	Endothelin B Receptor (cluster #1 Of 1), Eukaryotic	Eukaryotes	515	0.24	Binding ≤ 10μM
EDNRA-1-E	Endothelin Receptor ET-A (cluster #1 Of 1), Eukaryotic	Eukaryotes	0	0.00	Functional ≤ 10μM
EDNRB-1-E	Endothelin Receptor ET-B (cluster #1 Of 1), Eukaryotic	Eukaryotes	0	0.00	Functional ≤ 10μM

ChEMBL Target Annotations
Uniprot	Swissprot	Description	Affinity (nM)	LE (kcal/mol/atom)	Type
EDNRA_RAT	P26684	Endothelin Receptor ET-A, Rat	0.36	0.36	Binding ≤ 1μM
EDNRA_HUMAN	P25101	Endothelin Receptor ET-A, Human	0.1	0.38	Binding ≤ 1μM
EDNRB_PIG	P35463	Endothelin Receptor ET-B, Pig	515	0.24	Binding ≤ 1μM
EDNRB_HUMAN	P24530	Endothelin Receptor ET-B, Human	139	0.26	Binding ≤ 1μM
EDNRA_RAT	P26684	Endothelin Receptor ET-A, Rat	0.36	0.36	Binding ≤ 10μM
EDNRA_HUMAN	P25101	Endothelin Receptor ET-A, Human	0.1	0.38	Binding ≤ 10μM
EDNRB_PIG	P35463	Endothelin Receptor ET-B, Pig	515	0.24	Binding ≤ 10μM
EDNRB_HUMAN	P24530	Endothelin Receptor ET-B, Human	139	0.26	Binding ≤ 10μM
EDNRA_RAT	P26684	Endothelin Receptor ET-A, Rat	0.16	0.37	Functional ≤ 10μM
EDNRB_RAT	P21451	Endothelin Receptor ET-B, Rat	0.16	0.37	Functional ≤ 10μM

Description	Species
G alpha (q) signalling events	Sus scrofa (EDNRB_PIG) Homo sapiens (EDNRB_HUMAN) Rattus norvegicus (EDNRA_RAT)
Peptide ligand-binding receptors	Rattus norvegicus (EDNRA_RAT) Sus scrofa (EDNRB_PIG) Homo sapiens (EDNRB_HUMAN)