Type pH range	xlogP	Des A‑Pol Apolar desolvation (kcal/mol)	Des Pol Polar desolvation (kcal/mol)	H Don H-bond donors	H Acc H-bond acceptors	Chg Net charge	tPSA (Å²)	MWT Molecular weight (g/mol)	RB Rotatable bonds	DL
Hi High (pH 8-9.5)	4.60	11.15	-146.77	5	6	2	68	520.762	15	↓ MOL2 SDF SMILES Flexibase
Hi High (pH 8-9.5)	4.60	8.74	-5.27	3	6	0	62	518.746	15	↓ MOL2 SDF SMILES Flexibase
Hi High (pH 8-9.5)	4.60	9.4	-58.91	4	6	1	67	519.754	15	↓ MOL2 SDF SMILES Flexibase
Mid Mid (pH 6-8)	4.60	10.77	-102.07	5	6	2	65	520.762	15	↓ MOL2 SDF SMILES Flexibase
Mid Mid (pH 6-8)	4.60	11.52	-107.65	5	6	2	68	520.762	15	↓ MOL2 SDF SMILES Flexibase
Mid Mid (pH 6-8)	4.60	12.2	-207.9	6	6	3	69	521.77	15	↓ MOL2 SDF SMILES Flexibase

Clustered Target Annotations
Code	Description	Organism Class	Affinity (nM)	LE (kcal/mol/atom)	Type
OPRD-1-E	Delta Opioid Receptor (cluster #1 Of 3), Eukaryotic	Eukaryotes	4969	0.20	Binding ≤ 10μM
OPRK-4-E	Kappa Opioid Receptor (cluster #4 Of 6), Eukaryotic	Eukaryotes	8759	0.19	Binding ≤ 10μM
OPRM-1-E	Mu-type Opioid Receptor (cluster #1 Of 4), Eukaryotic	Eukaryotes	835	0.22	Binding ≤ 10μM

ChEMBL Target Annotations
Uniprot	Swissprot	Description	Affinity (nM)	LE (kcal/mol/atom)	Type
OPRM_RAT	P33535	Mu Opioid Receptor, Rat	835	0.22	Binding ≤ 1μM
OPRD_HUMAN	P41143	Delta Opioid Receptor, Human	4969	0.20	Binding ≤ 10μM
OPRK_HUMAN	P41145	Kappa Opioid Receptor, Human	8759	0.19	Binding ≤ 10μM
OPRM_RAT	P33535	Mu Opioid Receptor, Rat	835	0.22	Binding ≤ 10μM

Description	Species
G alpha (i) signalling events	Homo sapiens (OPRD_HUMAN) Rattus norvegicus (OPRM_RAT)
G-protein activation	Rattus norvegicus (OPRM_RAT)
Opioid Signalling	Rattus norvegicus (OPRM_RAT)
Peptide ligand-binding receptors	Homo sapiens (OPRD_HUMAN) Rattus norvegicus (OPRM_RAT)