| In ZINC since | Heavy atoms | Benign functionality |
|---|---|---|
| October 14th, 2009 | 21 | Yes |
Popular Name: [1,1' [1,1'
None
| Type pH range | xlogP | Des A‑Pol Apolar desolvation (kcal/mol) | Des Pol Polar desolvation (kcal/mol) | H Don H-bond donors | H Acc H-bond acceptors | Chg Net charge | tPSA (Ų) | MWT Molecular weight (g/mol) | RB Rotatable bonds | DL |
|---|---|---|---|---|---|---|---|---|---|---|
| Ref Reference (pH 7) | 3.97 | 2.8 | -8.21 | 3 | 3 | 0 | 61 | 278.307 | 2 | ↓ |
| Code | Description | Organism Class | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| ABL1-2-E | Tyrosine-protein Kinase ABL (cluster #2 Of 2), Eukaryotic | Eukaryotes | 8000 | 0.34 | Functional ≤ 10μM |
| BCR-2-E | Breakpoint Cluster Region Protein (cluster #2 Of 2), Eukaryotic | Eukaryotes | 8000 | 0.34 | Functional ≤ 10μM |
| Z80156-1-O | HL-60 (Promyeloblast Leukemia Cells) (cluster #1 Of 12), Other | Other | 9000 | 0.34 | Functional ≤ 10μM |
| Z80186-2-O | K562 (Erythroleukemia Cells) (cluster #2 Of 11), Other | Other | 8000 | 0.34 | Functional ≤ 10μM |
| Uniprot | Swissprot | Description | Affinity (nM) | LE (kcal/mol/atom) | Type |
|---|---|---|---|---|---|
| BCR_HUMAN | P11274 | Breakpoint Cluster Region Protein, Human | 8000 | 0.34 | Functional ≤ 10μM |
| Z80156 | Z80156 | HL-60 (Promyeloblast Leukemia Cells) | 3500 | 0.36 | Functional ≤ 10μM |
| Z80186 | Z80186 | K562 (Erythroleukemia Cells) | 8000 | 0.34 | Functional ≤ 10μM |
| ABL1_HUMAN | P00519 | Tyrosine-protein Kinase ABL, Human | 8000 | 0.34 | Functional ≤ 10μM |
| Description | Species |
|---|---|
| CDO in myogenesis | |
| Factors involved in megakaryocyte development and platelet production | |
| Regulation of actin dynamics for phagocytic cup formation | |
| Rho GTPase cycle | |
| Role of Abl in Robo-Slit signaling | |
| Signaling by FGFR1 fusion mutants |
